Transferrin receptor specific antibody-neuropharmaceutical agent

Details Transferrin receptor specific antibody-neuropharmaceutical agent Transferrin receptor specific antibody-neuropharmaceutical agent

1989-09-07

1992-10-13

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

424 852, 424 858, 424 943, 435188, 530302, 530311, 530370, 530351, 53038822, 5303911, 5303913, 5303915, 5303917, 5303919, 530399, A61K 3944, A61K 3748, C07K 1702, C12N 1106

Patent

active

051549247

ABSTRACT:
The present invention pertains to a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neuropharmaceutical agent conjugate wherein the antibody is reactive with a transferrin receptor. Other aspects of this invention include a delivery system comprising an antibody reactive with a transferrin receptor linked to a neuropharmaceutical agent and method for treating hosts afflicted with a disease associated with a neurological disorder.

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