Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-07
2000-01-18
Elliott, George C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 711, 4352521, 4353201, 530350, 536 231, C12P 2106, C12P 2104, C12N 112, C12N 1500
Patent
active
060156880
ABSTRACT:
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.
REFERENCES:
patent: 4258029 (1981-03-01), Moloney et al.
patent: 4496538 (1985-01-01), Gordon
patent: 4596792 (1986-06-01), Vyas
patent: 4599230 (1986-07-01), Milich et al.
patent: 4599231 (1986-07-01), Milich et al.
patent: 4601903 (1986-07-01), Frasch
patent: 4855283 (1989-08-01), Lockhoff et al.
patent: 4952496 (1990-08-01), Studier et al.
patent: 5141743 (1992-08-01), Schryvers
patent: 5194254 (1993-03-01), Barber et al.
Orkin et al., Report and recommendations of the panel to asses the NIH investment in research on gene therapy, Dec. 7, 1995.
Holland et al., Evidence for in vivo expression of transferrin binding proteins in Haemophilus influenzae type b, Infection and Immunity, v. 60(7), pp. 2986-2991, Jul. 1992.
Legrain et al., Cloning and characterization of the Neisseria meningitidis genes encoding the transferrin binding proteins Tbp 1 and Tbp2*, Gene, v. 130, pp. 73-80, Aug. 1993.
Loosmore et al., Cloning and expression of the Haemophilus influenzae transferrin receptor genes, Molecular Microbiology, v. 19(3), pp. 575-586, 1996.
Sambrook et al., Molecular Cloning: a laboratory manual, Cold Spring Harbor Press, chapters 16-17, 1989.
Vonder Haar et al., Characterization of a highly structured domain in Tbp2 from Neisseria meningitidis involved in binding to human transferrin, Journal of Bacteriology, v. 176(20), pp. 6207-6213, Oct. 1994.
Barcak et al, (1991) Methods Enzymol. 204: 321-342.
Berkowitz et al, (1987) J. Pediatr. 110:509.
Black et al, (1991) Pediatr. Infect. Dis. J. 10:97.
Bluestone, N. (1982) Engl. J. Med. 306;1399.
Chang et al, (1978) Nature 375:615.
Claesson et al, (1989) J. Pediatr. 114:97.
Cornelissen et al, (1992) J. Bacteriol. 174:5788.
Danve, et al, (1993) Vaccine 11, 1214-1220.
Deres et al, (1989) Nature 342;651.
Gerlach et al, (1992) Infect. Immun. 608:325.
Goeddel et al, (1979) Nature 281:544.
Chou et al, (1978) Annual Reviews of Biochemistry 47, 251-276.
Harkness et al, (1992) J. Bacteriol. 174:2425.
Holland et al, (1992) Infect. Immun. 60:2986.
Hopp. T.P., (1986) Journal of Immunological Methods 88:1-18.
Itakura et al, (1977) Science 198:1056.
Jarosik et al, (1994) Infection and Immunity 62: 2470-2477.
Legrain et al, (1993) Gene 130:73.
Lockhoff et al, (1991) Chem. Int. Ed. Engl. 30:1611.
Mickelsen and Sparling, (1981) Infect. Immun. 33:555.
Morton et al, (1993) Infection and Immunity 61: 4033-4037.
Murdin et al, (1992) J. Gen. Viral 73:607.
Murdin et al, (1991) Microbial Pathogenesis 10:27.
Nixon-George et al (1990) J. Immunol. 14:4798.
Ogunnariwo et al, (1992) Avian Dis. 36:655.
O'Hagan (1992) Clin. Pharmokinet. 22:1.
Panezutti et al, (1993) Infection and Immunity, 61:1867-1872.
Roosi-Campos et al, (1992) Vaccine 10,:512-518.
Schryvers, (1988) Molec. Microbiol. 2:467.
Schryvers and Lee, (1989) Can. J. Microbiol. 35:409.
Schryvers and Gray-Owen, (1992) J. Infect. Dis. 165 suppl 1:S103.
Schryvers (1989) Med. Microbiol. 29:121.
Short et al, (1988) Nucl. Acids Res. 16:7583.
Ulmer et al (1993) Curr. Opinion Invest. Drugs. 2(9):983-989.
VanderWerf et al, (1986) Proc. Natl. Acad. Sci. 83:2330.
Weismuller et al, (1989) Vaccine 8:29.
Wilton et al, (1993) FEMS Microbiology Letters 107:59-66.
Sambrook et al, Molecular Cloning, A Lab Manual. vol. 3, pp. 16.2, 16.3 and pp. 17.2-17.28.
Ghrayeb et al, Embo J. vol. 3, pp. 2437-2442, (1984).
Thomas et al, methods in Enzymology, vol. 182, pp.499-520, (1990).
Gray-Owen et al, Infect. Immun., vol 63; No. 4 (1995) pp. 1201-1210.
Griffiths et al, Fems Microbiol. Lett. vol. 109, No. 1 -May 1993. pp. 85-91 .
Chong Pele
Gray-Owen Scott
Harkness Robin
Klein Michel
Loosmore Sheena
Connaught Laboratories Limited
Elliott George C.
Wang Andrew
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