Transfer compounds, production and use thereof

Details Transfer compounds, production and use thereof Transfer compounds, production and use thereof

2007-03-13

2007-03-13

Priebe, Scott D. (Department: 1633)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S358000

Reexamination Certificate

active

10152212

ABSTRACT:
The invention relates to the use of a carboxy-terminal fragment of the Ki-67 protein or of an active part, fragment or homologue thereof as a compound that can be used for intracellular transfer and for the introduction in and the release by the cells. The invention further relates to transfer compounds that contain the above-mentioned Ki-67 protein and to the vectors encoding the same. The invention also relates to corresponding pharmaceutical compositions and to the use of the transfer protein as an excipient or active agent in the treatment of diseases.

REFERENCES:
patent: WO 97/05265 (1997-02-01), None
patent: WO 99/61607 (1999-12-01), None
MacCallum, D. et al., “The biochemical characterization of the DNA binding activity of pKi67”, Jun. 2000, J. Pathol., vol. 191: pp. 286-298.
Schlüter et al., 1993,J. Cell Biol.123(3): 513-522.
Ducurow, M., Cell Proliferation-Associated Nuclear Antigen Defined by Antibody Ki-67: a New Kind of Cell Cycle-Maintaining Proteins, Archivum Immunologiae et Therapiae Experimentalis, 1994, 43, 117-121.
Gene Expression, Voyager™ Vectors, Invitrogen pamphlet, pp. 104, 105, 109.
Madshus, I., Entry of Diphtheria Toxin-Protein A Chimeras into Cells, The Journal of Biological Chemistry, vol. 266, No. 26, Issue of Sep. 15, 1991, pp. 17446-17453.
Schluter, C., The Cell Proliferation-associated Antigen of Antibody Ki-67: A very Large, Ubiquitous Nuclear Protein with Numerous Repeated Elements, Representing a New Kind of Cell Cycle-maintaining Proteins, The Journal of Cell Biology, vol. 123, No. 3, Nov. 1993, p. 513-522.
Scholzen, C. Evidence for a role of the Ki-67 repeats in guiding the Ki-67 protein to the nucleoli and the perichromosomal layer, (abstract only).
Shayan, P., The proliferation-associated nuclear protein Ki-67 in the bovine system: partial characterization and its application for determination of the proliferation of Theileria-infected bovine cells, Springer-Vertag 1999, pp. 613-620.
Wiedlocha, A., Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector, The EMBO Journal, vol. 11 No. 13, pp. 4835-4842, 1992.

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