Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2006-12-05
2006-12-05
Davis, Brian (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S292000, C564S294000, C564S504000, C564S505000, C514S642000, C514S667000, C514S668000, C514S669000, C514S670000, C435S458000
Reexamination Certificate
active
07145039
ABSTRACT:
Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure:whereinQ is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L′—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of R1, R3, R4and R6is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and anyone of R1, R3, R4and/or R6may optionally be covalently linked with each other, with Y or with L when L is C or CH to form a cyclic moiety; Z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; X1and X2, independently of one another, are selected from the group consisting of NH, O, S, alkylene, and arylene; L′ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; D is Q or a bond; A1and A2, independently of one another, are selected from the group consisting of CH2O, CH2S, CH2NH, C(O), C{NH), C(S) and (CH2)t; X is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.
REFERENCES:
patent: 2654785 (1953-10-01), Miescher et al.
patent: 2695314 (1954-11-01), Kosmin
patent: 2867665 (1959-01-01), Dornfield
patent: 2901461 (1959-08-01), Auerbach et al.
patent: 3152188 (1964-10-01), Kirkpatrick
patent: 3324182 (1967-06-01), De Brunner et al.
patent: 3369905 (1968-02-01), Jones et al.
patent: 4143003 (1979-03-01), Haas et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4501728 (1985-02-01), Geho et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4737323 (1988-04-01), Martin et al.
patent: 4767699 (1988-08-01), Vary et al.
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4812449 (1989-03-01), Rideout
patent: 4837028 (1989-06-01), Allen
patent: 4889818 (1989-12-01), Gelfand et al.
patent: 4889953 (1989-12-01), Inoue et al.
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 4946787 (1990-08-01), Eppstein et al.
patent: 4959217 (1990-09-01), Sanders et al.
patent: 4962022 (1990-10-01), Fleming et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 4967008 (1990-10-01), Friedli et al.
patent: 5047342 (1991-09-01), Chatterjee
patent: 5049386 (1991-09-01), Eppstein et al.
patent: 5079352 (1992-01-01), Gelfand et al.
patent: 5091576 (1992-02-01), Bergeron
patent: 5165925 (1992-11-01), Leong
patent: 5166320 (1992-11-01), Wu et al.
patent: 5171678 (1992-12-01), Behr et al.
patent: 5186923 (1993-02-01), Piwnica-Worms et al.
patent: 5187085 (1993-02-01), Lee
patent: 5198423 (1993-03-01), Taguchi et al.
patent: 5208036 (1993-05-01), Eppstein et al.
patent: 5244797 (1993-09-01), Kotewicz et al.
patent: 5264423 (1993-11-01), Cohen et al.
patent: 5264618 (1993-11-01), Felgner et al.
patent: 5266106 (1993-11-01), Breton
patent: 5270179 (1993-12-01), Chatterjee
patent: 5276019 (1994-01-01), Cohen et al.
patent: 5277897 (1994-01-01), Piwnica-Worms et al.
patent: 5279833 (1994-01-01), Rose
patent: 5283185 (1994-02-01), Epand et al.
patent: 5286717 (1994-02-01), Cohen et al.
patent: 5328470 (1994-07-01), Nabel et al.
patent: 5328984 (1994-07-01), Pastan et al.
patent: 5334761 (1994-08-01), Gebeyehu et al.
patent: 5338532 (1994-08-01), Tomalia et al.
patent: 5350672 (1994-09-01), Oberst et al.
patent: 5354844 (1994-10-01), Beug et al.
patent: 5374553 (1994-12-01), Gelfand et al.
patent: 5409818 (1995-04-01), Davey et al.
patent: 5436149 (1995-07-01), Barnes
patent: 5455166 (1995-10-01), Walker
patent: 5455335 (1995-10-01), Kahne et al.
patent: 5459127 (1995-10-01), Felgner et al.
patent: 5484702 (1996-01-01), Ludwig
patent: 5498522 (1996-03-01), Porter
patent: 5498523 (1996-03-01), Tabor et al.
patent: 5500356 (1996-03-01), Li et al.
patent: 5506212 (1996-04-01), Hoke et al.
patent: 5510239 (1996-04-01), Baracchini, Jr. et al.
patent: 5510476 (1996-04-01), Ravikumar et al.
patent: 5512438 (1996-04-01), Ecker
patent: 5512462 (1996-04-01), Cheng
patent: 5514577 (1996-05-01), Draper et al.
patent: 5514787 (1996-05-01), Atkinson
patent: 5519134 (1996-05-01), Acevedo et al.
patent: 5521291 (1996-05-01), Curiel et al.
patent: 5521302 (1996-05-01), Cook
patent: 5527524 (1996-06-01), Tomalia et al.
patent: 5527928 (1996-06-01), Nantz et al.
patent: 5532142 (1996-07-01), Johnston et al.
patent: 5541307 (1996-07-01), Cook et al.
patent: 5543507 (1996-08-01), Cook et al.
patent: 5545412 (1996-08-01), Eppstein et al.
patent: 5545540 (1996-08-01), Mian
patent: 5547932 (1996-08-01), Curiel et al.
patent: 5550289 (1996-08-01), Eppstein et al.
patent: 5554746 (1996-09-01), Ravikumar et al.
patent: 5560929 (1996-10-01), Hedstrand et al.
patent: 5574142 (1996-11-01), Meyer, Jr. et al.
patent: 5578475 (1996-11-01), Jessee
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5583198 (1996-12-01), Whittaker
patent: 5587441 (1996-12-01), Frechet et al.
patent: 5587446 (1996-12-01), Frechet et al.
patent: 5589392 (1996-12-01), Short
patent: 5589466 (1996-12-01), Felgner et al.
patent: 5595096 (1997-01-01), Coffman
patent: 5595897 (1997-01-01), Midoux et al.
patent: 5596091 (1997-01-01), Switzer
patent: 5602240 (1997-02-01), De Mesmaeker et al.
patent: 5614365 (1997-03-01), Tabor et al.
patent: 5627159 (1997-05-01), Shih et al.
patent: 5631329 (1997-05-01), Yin et al.
patent: 5635487 (1997-06-01), Wolff et al.
patent: 5641662 (1997-06-01), Debs et al.
patent: 5650096 (1997-07-01), Harris et al.
patent: 5658776 (1997-08-01), Flotte et al.
patent: 5661025 (1997-08-01), Szoka, Jr. et al.
patent: 5667774 (1997-09-01), Figuly
patent: 5670347 (1997-09-01), Gopal
patent: 5674908 (1997-10-01), Haces et al.
patent: 5676954 (1997-10-01), Brigham
patent: 5681944 (1997-10-01), Crooke et al.
patent: 5691460 (1997-11-01), Duvic et al.
patent: 5693509 (1997-12-01), Cotten et al.
patent: 5693773 (1997-12-01), Kandimalla et al.
patent: 5703055 (1997-12-01), Felgner et al.
patent: 5705385 (1998-01-01), Bally et al.
patent: 5714166 (1998-02-01), Tomalia et al.
patent: 5719131 (1998-02-01), Harris et al.
patent: 5726298 (1998-03-01), Hirai et al.
patent: 5736387 (1998-04-01), Paul et al.
patent: 5736392 (1998-04-01), Hawley-Nelson et al.
patent: 5744335 (1998-04-01), Wolff et al.
patent: 5744625 (1998-04-01), Nantz et al.
patent: 5753613 (1998-05-01), Ansell et al.
patent: 5756353 (1998-05-01), Debs
patent: 5759778 (1998-06-01), Li et al.
patent: 5759805 (1998-06-01), Feldhaus et al.
patent: 5773527 (1998-06-01), Tomalia et al.
patent: 5780053 (1998-07-01), Ashley et al.
patent: 5783565 (1998-07-01), Lee et al.
patent: 5783566 (1998-07-01), Mislick
patent: 5785992 (1998-07-01), Ansell et al.
patent: 5795587 (1998-08-01), Gao et al.
patent: 5807746 (1998-09-01), Lin et al.
patent: 5824812 (1998-10-01), Nantz et al.
patent: 5827703 (1998-10-01), Debs et al.
patent: 5830430 (1998-11-01), Unger et al.
patent: 5830878 (1998-11-01), Gorman et al.
patent: 5834439 (1998-11-01), Haces et al.
patent: 5837092 (1
Chu Yongliang
Gebeyehu Gulilat
Masoud Malek
Davis Brian
Greenlee Winner and Sullivan PC
Invitrogen Corp.
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