Transfection of lung via aerosolized transgene delivery

Details Transfection of lung via aerosolized transgene delivery Transfection of lung via aerosolized transgene delivery

1993-03-10

1997-06-24

Rories, Charles C. P.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4351723, 4353201, 424450, 514 44, 12820014, 12820024, 536 241, 436 71, C12N 1564, C12N 1587, A61K 4800, A61K 9127

Patent

active

056416628

ABSTRACT:
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Lipid carrier-nucleic acid complexes are prepared then delivered via aerosol to the lung airway. The invention provides a direct method for transforming pulmonary cells as a means for treating disorders of the lung as for providing a means for delivering substances systematically following expression in the lung.

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