Transfected human amniotic cells and method for producing a gene

Details Transfected human amniotic cells and method for producing a gene Transfected human amniotic cells and method for producing a gene

1996-04-30

2000-09-12

Hauda, Karen M.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435375, C12N 1563

Patent

active

061176761

ABSTRACT:
The present invention provides a human amniotic cell in which a gene desired to be expressed is introduced, and wherein said human amniotic cell expresses the product encoded by said gene. The present invention also provides a method for treating hereditary diseases comprising transplanting the human amniotic cells.

REFERENCES:
Orkin et al. "Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy," NIH Report, Dec. 7, 1995.
Maurer et al. "The Use of Gamma-Interferon to Increase HLA Antigen Exrpession on Cultured Amniotic Cells Used for the Prenatal Diagnosis of 21-Hydroxylase Deficiency," Annals of the New York Academy of Sciences, vol. 458: 148-155, 1985.
Maurer et al. "Gamma Interferon Induces Dedtectable Serological and Functional Expression of DR and DP but not DQ antigens on cultured amniotic fluid cells," Tissue Antigens, vol. 31: 174-182, 1987.
Raniero et al. "Trans-Activation of Herpes Simplex Virus Type-1 Immediate Early Genes is Specifically Inhibited by Human Recombinant Interferons," vol. 159(2): 439-444, Mar. 15, 1996.
Mahieu et al. "Construction of a Ribozyme Directed against Human Interleukin-6 mRNA Evaluation of Its Catalytic Activity In Vitro and In Vivo," Blood, vol. 84(11): 3758-3765, Dec. 1, 1994.
Grunhaus et al. "Adenovirus as cloning vectors," Seminars in Virology, vol. 3: 237-252, 1992.

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