Transesterification process for otereoselection of enantiomers o

Details Transesterification process for otereoselection of enantiomers o Transesterification process for otereoselection of enantiomers o

1992-08-24

1993-10-26

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435135, 435874, C12P 4100, C12P 762

Patent

active

052565696

ABSTRACT:
An optically active alcohol of this invention is obtained from a process using an enzyme having the ability to conduct preferentially a transesterification reaction with a triglyceride and an (R,S)-alcohol represented by a general formula: ##STR1## wherein X indicates alkyl group having a carbon number of 2-10, Y indicates alkyl group having a carbon number of 1-3, CF.sub.3 or CN, and X.noteq.Y. In this process, the (R,S)-alcohol of the above formula (1) and the triglyceride are reacted under substantially anhydrous conditions. The obtained ester is resolved and the optically active alcohol which contains richly either R- or S-alcohol is produced the optically active alcohol is efficiently obtained by an industrially advantageous biochemical method.

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Kirchner et al, "Resolution of Racemic Mixtures Via Lipase Catalysis in Organic Solvents", J. Am. Chem. Soc. v. 107, 7072-76, 1985.
Cambou et al (A), "Unusual Catalytic Properties of Usual Enzymes", New York Academy of Sciences, v. 434, 219-223, 1984.
Cambou et al (B), "Preparative Production of Optically Active Esters and Alcohols Using Esterase-Catalyzed Stereospecific Transesterification in Organic Media" J. Am. Chem. Soc. v. 106, 2687-2692, 1984.
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