Transepithelial transport of molecular species

Details Transepithelial transport of molecular species Transepithelial transport of molecular species

2006-10-10

2006-10-10

Ungar, Susan (Department: 1642)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S132100, C424S136100, C424S141100, C424S152100, C424S156100, C530S391100, C530S391500, C530S391700

Reexamination Certificate

active

07118741

ABSTRACT:
There is disclosed a synthetic cross-linker protein capable of binding a molecule or macromolecular species to a transcytosis receptor for transport of the molecule or macromolecule species across a mucous membrane, said cross-linker protein comprising a first binding region capable of binding selectively to a site on the said molecule or macromolecular species to be transported and a second binding region capable of binding selectively to a site on said receptor, wherein the first binding region is the antigen-binding site of a first antibody molecule having specificity for an antigenic site on said molecule or macromolecular species to be transported and the second binding region is the antigen-binding site of a second antibody molecule which has specificity for an antigenic site on the said transcytosis receptor.

REFERENCES:
patent: 0255249 (1995-04-01), None
patent: WO 89/01343 (1989-02-01), None
patent: WO 90/08779 (1990-08-01), None
Kaetzel et al (PNAS, 88:8796-8800), 1991.
Kaetzel et al (J. Immunol., 152:72-76), 1994.
Fahey et al (Clin. Exp. Immunol., 88:1-5), 1992.
Fox (B90/Technology, 12:128), 1994.
Adorini et al (Immunol. Today, 11:383-386), 1990.
Klausner (Biotechnology, 4:103-104), 1985.
Blanco Quiros et al (Eur. J. Pediatr, 1994, 153:103-106).
Taber's Cyclopedic Medical Dictionary, (FA. Davis Company, Philadelphia, 1989, p. 1807).
Johnstone and Thorpe (Immunochemistry in Practice, Blackwell Scientific Publications, Oxford, 1987, pp 49-50).
Kraehenbuhl, J.P., et al., “Receptor-Mediated Transepithelial Transport of Secretory Antibodies and Engineering of Mucosal Antibodies”, Chem. Abstracts, vol. 110, No. 3, Jan. 16, 1989, Abstract No. 19368n, p. 145.
Kraehenbuhl, J.P., et al., “Receptor-Mediated Transepithelial Transport of Secretory Antibodies and Engineering of Mucosal Antibodies”, Adv. Exp. Med. Biol., vol. 216B, 1989, pp. 1053-1060.

Affiliated with

Also associated with

Rating

Transepithelial transport of molecular species does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transepithelial transport of molecular species, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transepithelial transport of molecular species will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3705483