Transductin-1 and transductin-2 and applications to...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S252300, C435S254110, C435S320100, C435S325000, C435S348000, C514S04400A, C536S023500

Reexamination Certificate

active

10792307

ABSTRACT:
The invention provides an isolated or purified nucleic acid molecule consisting essentially of the nucleotide sequence encoding transductin-2 (TDC2), related and derivative nucleic acid molecules, vectors comprising the isolated or purified nucleic acid sequences, cells comprising such vectors, polypeptides encoded by the nucleic acid molecules, monoclonal antibodies and cell lines producing the monoclonal antibodies. The invention also provides methods of treating, prognosticating and monitoring hearing loss.

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patent: WO 01/75067 (2001-10-01), None
patent: WO 02/068579 (2002-09-01), None
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Jain et al., “A Human Recessive Neurosensory Nonsyndromic Hearing Impairment Locus is a Potential Homologue of the Murine Deafness (dn) Locus,”Hum. Mol. Genet., vol. 4 (12), pp. 2391-2394 (1995).
Kurima et al., “Genetic Map Localization of DFNA34 and DFNA26, Two Autosomal Dominant Non-Syndromic Deafness Loci,”Am. J. Hum. Genet., vol. 67, p. 300, Poster No. 1654 (2000).
Kurima, et al., “Dominant and Recessive Deafness Caused by Mutations of a Novel Gene,TMC1, Required for Cochlear Hair-Cell Function,”Nat. Genet., vol. 30, pp. 277-284 (2002).
Scott et al., “Refining the DFNB7-DFNB11 Deafness Locus Using Intragenic Polymorphisms in a Novel Gene,TMEM2,”Gene, vol. 246, pp. 265-274 (2000).

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