Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Nucleoproteins – e.g. – chromatin – chromosomal proteins,...
Patent
1995-06-02
1999-12-28
Prouty, Rebecca E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Nucleoproteins, e.g., chromatin, chromosomal proteins,...
530350, 536 235, C07K 1482, C12N 1512
Patent
active
060083239
ABSTRACT:
The present invention provides a transrepressing protein of the Fos proto-oncogene family. The protein, FosB2, is characterized by having a leucine zipper domain and forming a heterodimer with a Jun related protein. This heterodimer is capable of binding to an AP-1 site and suppressing transcriptional transactivation of a promoter containing the AP-1 site.
REFERENCES:
P. Sassone-Corsi et al., "Direct Interaction Between Fos and Jun Nuclear Oncoproteins: Role of the Leucine Zipper Domain", Nature 336: 692-695, Dec. 1988.
Y. Nakabeppu et al., "Anaturally Occuring Truncated Form of FosB That Inhibits Fos/Jun Transcriptional Activity", Cell 64: 751-759, Feb. 1991.
T. Noguchi et al., "Genomic Structure of the FosB Gene: Differential Splicing Give Rise to Two Transcripts", J. Cell. Biochem. Suppl. 15B: 215, Jan. 1991.
Verma Inder M.
Wisdom Ronald M.
Yen Jong-Young J.
Prouty Rebecca E.
The Salk Institute for Biological Studies
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