Transdominant negative proto-oncogene

Details Transdominant negative proto-oncogene Transdominant negative proto-oncogene

1994-03-28

1995-11-28

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 691, 4351723, 4352523, 4353201, 536 231, 536 235, 536 245, 935 11, 935 27, 935 32, 935 36, 935 54, 935 57, 935 62, 935 66, C12N 1512, C12N 510, C12N 1579, C12N 1586

Patent

active

054707366

ABSTRACT:
The present invention provides polynucleotide and polypeptide sequences for a trans-repressing protein of the Fos proto-oncogene family, where the polypeptide is characterized by having a leucine zipper domain and forming a heterodimer with a Jun related protein. This heterodimer is capable of biding to an AP-1 site and suppressing transcriptional transactivation of a promoter containing the AP-1 site.

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