Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Patent
1985-07-02
1987-09-01
Rosenbaum, C. Fred
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
128156, 424448, 424449, 424486, A61K 900
Patent
active
046906835
ABSTRACT:
A transdermal drug delivery device for administering 5-[(3,4-dimethoxyphenethyl) methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile comprising a permeable matrix of silicone elastomer or other bioacceptable lipophilic polymer material having an effective cardiovascular affecting amount of active drug and an effective drug release promoting amount of a transport enhancing agent dispersed therein. The back of the matrix is covered with an occlusive backing and the face of the matrix is covered with a biocompatible adhesive such as a silicone adhesive also having a transport enhancing agent dispersed therein. A supply of skin permeation enhancing agent may be provided adjacent the adhesive layer such that the skin of a patient to whom the device is applied is pretreated with permeation enhancing agent. Particularly preferred skin permeation and transport enhancing agents include N,N-diethyl-m-toluamide, isopropyl myristate and similar compounds.
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Chien Yie W.
Tojo Kakuji
Rosenbaum C. Fred
Rutgers The State University of New Jersey
Smith, Jr. Jerome R.
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