Transdermal therapeutical system with physostigmine as active co

Details Transdermal therapeutical system with physostigmine as active co Transdermal therapeutical system with physostigmine as active co

1993-04-26

1995-02-21

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424448, 424485, 424486, 424487, A61F 1302

Patent

active

053913752

ABSTRACT:
The present invention relates to a transdermal therapeutical system for the administration of physostigmine to the skin via a backing layer which is impermeable to active substances, an active substance deposit comprising at least one auxiliary agent with supporting and distributing function in the form of a textile fabric material, a matrix surrounding said deposit from all sides, and optionally a removable protective layer, the matrix of which comprises 10-90%-wt polymeric material selected from the group consisting of polymers on the basis of acrylate and/or methacrylate and esters of hydrogenated colophonium, 0-30%-wt softener on the basis of hydrocarbons and/or esters, and that the active substance deposit immediately after its production comprises 15-85%-wt of a 0.1-70%-wt physostigmine solution.

REFERENCES:
patent: 3996934 (1976-12-01), Zaffaroni
patent: 4668506 (1987-05-01), Bawa
patent: 4765985 (1988-08-01), Leeson
patent: 4788063 (1988-11-01), Fisher
patent: 4917676 (1990-04-01), Heiber et al.
patent: 5089267 (1992-02-01), Hille
Drora Levy, "A Novel Transdermal Therapeutic System as a Potential Treatment for Alzheimer's Disease," in Adv. Behav. Biol., 1986, pp. 567-563.

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