Transdermal therapeutical system comprising physostigmine as act

Details Transdermal therapeutical system comprising physostigmine as act Transdermal therapeutical system comprising physostigmine as act

1989-12-18

1992-02-18

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424448, 424485, 424486, 424487, 4241961, 514783, 514879, A61F 1302, A61L 1544, A61K 970, A61K 3140

Patent

active

050892673

ABSTRACT:
The present invention relates to a transdermal therapeutical system for the administration of physostigmine to the skin via a cover layer which is impermeable to active substances, a pressure-sensitive adhesive reservoir layer, and optionally a removable protective layer, said reservoir layer consisting of 10-90% polymeric material selected from the groups consisting of block copolymers on the basis of styrene and 1,3-dienes, polyisobutylenes, polymers on the basis of acrylates and/or methacrylates and esters of hydrogenated colophonium, 0-30%-wt softeners on the basis of hydrocarbons and/or esters, and 0.1-20%-wt physostigmine.

REFERENCES:
patent: 3996934 (1976-12-01), Zaffaroni
patent: 4668506 (1987-05-01), Bawa
patent: 4765985 (1988-08-01), Leeson
patent: 4788063 (1988-11-01), Fisher et al.
patent: 4911707 (1990-03-01), Heiber et al.
Grant & Hackh's Chemical Dictionary, 5th Ed., pp. 146, 510.
The Merck Index, S. Budavari Ed., Merck & Co; Rahway, N.J., 1989, p. 1172.

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