Transdermal therapeutic system for the release of 17-.beta.-estr

Details Transdermal therapeutic system for the release of 17-.beta.-estr Transdermal therapeutic system for the release of 17-.beta.-estr

1997-06-16

1999-06-15

Brouillette, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61F 1302

Patent

active

059120088

ABSTRACT:
The invention concerns a transdermal therapeutic system comprising the active substance 17-.beta.-estradiol and optionally further active substances, with a laminated structure comprising a backing layer which is substantially impermeable to moisture and impermeable to active substance, one or more matrix layers and, where non-adhesive matrix layers are present, an adhesive layer, characterized in that the concentration of the dissolved estradiol in all matrix layers and, where an adhesive layer is present, in the adhesive layer lies between its saturation concentration in dry condition und its saturation concentration in moist condition, whereby the term "dry condition" is understood to mean that the base material is in equilibrium with a gas phase with less than 10% relative humidity and the term "moist condition" is understood to mean that the base material is in equilibrium with a gas phase with more than 90% relative humidity.

REFERENCES:
patent: 4668232 (1987-05-01), Cordes
patent: 4863738 (1989-09-01), Taskovich
patent: 5393529 (1995-02-01), Hoffmann

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