Transdermal therapeutic formulation and a method of administrati

Details Transdermal therapeutic formulation and a method of administrati Transdermal therapeutic formulation and a method of administrati

1992-08-13

1998-04-28

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424448, 424449, 523111, 602 52, 602 54, A61K 914

Patent

active

057441626

ABSTRACT:
A transdermal therapeutic formulation is made of a composition comprising a polymer and ingredients mixed with the polymer which are a pharmacologically active substance, an alcohol, a percutaneous absorption promoter utilized according to necessity and water utilized according to necessity. The polymer comprises lipophilic monomer units and hydrophilic monomer units in a specific ratio. The alcohol, the percutaneous absorption promoter and water are mixed with the polymer in specific amounts. The transdermal therapeutic formulation has excellent percutaneous absorption, has many kinds of applicable pharmacologically active substances, shows good stability of percutaneous absorption with time because of absence of crystallization of the pharmacologically active substance, has good adhesive strength and thus favorably utilized as transdermal therapeutic plaster.

REFERENCES:
patent: 4291015 (1981-09-01), Keith et al.
patent: 4482534 (1984-11-01), Blank
patent: 4789547 (1988-12-01), Song et al.
patent: 4914140 (1990-04-01), Saitoh
patent: 5133970 (1992-07-01), Petereit
patent: 5186938 (1993-02-01), Sablotsky

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