Transdermal systemic dosage forms

Details Transdermal systemic dosage forms Transdermal systemic dosage forms

1983-04-12

1986-04-29

Rosenbaum, C. Fred

Surgery

Controlled release therapeutic device or system

Osmotic or diffusion pumped device or system

604892, 604307, A61M 700

Patent

active

045854521

ABSTRACT:
Sustained release dosage forms that provide transdermal delivery of drugs utilizing the skin as the rate controlling membrane for the drugs. Methods for producing the dosage forms are also disclosed. The dosage forms are laminates produced by heating a laminate to a glass transition temperature of an outer removable layer of the laminate. While maintaining the laminate at the glass transition temperature, a vacuum is applied to draw the laminate into a suitable shape for a drug reservoir. An aqueous solvent is added to the reservoir and a semipermeable barrier layer is placed over the aqueous solvent in the reservoir. A pharmaceutically active drug is contained in the aqueous reservoir and this drug moves transdermally to provide the active ingredient to the patient.

REFERENCES:
patent: 2561071 (1949-09-01), Prisk
patent: 3797494 (1974-04-01), Laffaroni
patent: 3964482 (1976-06-01), Gerstel et al.
patent: 4291015 (1981-09-01), Keith et al.
patent: 4460372 (1984-07-01), Campbell et al.

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