Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Patent
1995-07-25
1999-12-14
Bawa, Raj
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
604 2, 424448, 424449, A61B 1700
Patent
active
060029617
ABSTRACT:
Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).
REFERENCES:
patent: 3551554 (1970-12-01), Herschler
patent: 3711602 (1973-01-01), Herschler
patent: 3711606 (1973-01-01), Herschler
patent: 4002221 (1977-01-01), Buchalter
patent: 4127125 (1978-11-01), Takemoto et al.
patent: 4144646 (1979-03-01), Takemoto et al.
patent: 4176664 (1979-12-01), Kalish
patent: 4249531 (1981-02-01), Hiller et al.
patent: 4280494 (1981-07-01), Cosgrove, Jr. et al.
patent: 4309989 (1982-01-01), Fahim
patent: 4372296 (1983-02-01), Fahim
patent: 4537776 (1985-08-01), Cooper
patent: 4557943 (1985-12-01), Rosler et al.
patent: 4563184 (1986-01-01), Korol
patent: 4646725 (1987-03-01), Moasset
patent: 4698058 (1987-10-01), Greenfeld et al.
patent: 4767402 (1988-08-01), Kost
patent: 4780212 (1988-10-01), Kost et al.
patent: 4787888 (1988-11-01), Fox
patent: 4820720 (1989-04-01), Sanders et al.
patent: 4821740 (1989-04-01), Tachibana et al.
patent: 4834978 (1989-05-01), Nuwayser
patent: 4855298 (1989-08-01), Yamada et al.
patent: 4860058 (1989-08-01), Kobayashi et al.
patent: 4863970 (1989-09-01), Patel et al.
patent: 4953565 (1990-09-01), Tachibana et al.
patent: 5006342 (1991-04-01), Cleary et al.
patent: 5007438 (1991-04-01), Tachibana
patent: 5016615 (1991-05-01), Driller
patent: 5076273 (1991-12-01), Schoendorfer et al.
patent: 5115805 (1992-05-01), Bommannan et al.
patent: 5139023 (1992-08-01), Stanley et al.
patent: 5140985 (1992-08-01), Schroder et al.
patent: 5171215 (1992-12-01), Flanagan
patent: 5197946 (1993-03-01), Tachibana
patent: 5231975 (1993-08-01), Bommannan et al.
patent: 5267985 (1993-12-01), Shimada
patent: 5315998 (1994-05-01), Tachibana et al.
patent: 5323769 (1994-06-01), Bommannan et al.
patent: 5386837 (1995-02-01), Sterzer
patent: 5401237 (1995-03-01), Tachibana et al.
patent: 5405614 (1995-04-01), D'Angelo et al.
patent: 5415629 (1995-05-01), Henley
patent: 5421816 (1995-06-01), Lipkovker
patent: 5445611 (1995-08-01), Eppstein et al.
patent: 5458140 (1995-10-01), Eppstein et al.
Egorov, E.A. et al.,. "use of the Variants of the Pharmacophysical Influence in Ophthalmology", 102 Ophthamology Journal #2 (1992).
Eppstein, D.A. et al.,"Applications of Liposome Formulations for Antimicrobial/Antiviral Therapy" Liposomes as Drug Carriers 311, 315 (G. Gregoriadis ed. 1988).
Eppstein, D.A., "Medical Utility of Interferons: Approaches to Increasing Therapeutic Efficacy" 7 Pharmacy International 195-198 (1986).
Eppstein, D.A. et al., "Alternative Delivery Systems for Peptides and Proteins as Drugs" 5 CRC Reviews in Therapeutic Drug Carrier Systems 99, 125 (1988).
Ulashik, V.S. et al., Ultrasound Therapy (Minsk, Belarus 1983).
Apfel, R.E., Possibility of Microcavitation from Diagnostic Ultrasound, IEEE Trans. Ultrason. Ferroelectronics Freq. Control UFFC-33:139-142 (1986).
Aungst et al., "Contributions of Drug Solubilization, Partioning, Barrier Disruption, and Solvent Permeation to the Enhancement of Skin Permeation of Various Compounds with Fatty Acids and Amines," Pharm. Res. 7:712-718 (1990).
Barry, "Mode of Action of Penetration Enhancers in Human Skin," J. Controlled Rel. 6:85-97 (1987).
Bommer, et al., "Subcutaneous Erythropoeitin," Lancet 406 (1988).
Burnette, R. R., "Iontophoresis," Transdermal Drug Delivery Developmental Issues and Research Initiatives (Hardgraft and Guv. Editors, Marcel Dekker, 247-291, 1989).
Cleary, Gary W., "Transdermal Controlled Release Systems," Medical Applications of Controlled Release (Langer and Wise, Editors, CRCPress 203-251, 1984).
Clegg and Vaz, "Translational diffusion of proteins and lipids in artificial lipid bilayer membranes. A comparison of experiment with theory," Progress in Protein-Lipid Interactions Watts, ed. (Elsvier, NY 1985) Chapter 5:173-229.
Davis, J. et al., "Characterization of Recombinant Human Erythropoietin Produced in Chinese Hamster Ovary Cells," Biochemistry 26:2633-2638 (1987).
Ebert, et al., "Transbuccal Absorption of Diclofenac Sodium in a Dog Model," Controlled Release Technology Pharmaceutical Application (Lee, et al. Editors, American Chemical Society)310-321 (1987).
Eggerth, et al., "Evaluation of Hamster Cheek Pouch as a Model for Buccal Absorption," Proceed. Intern. Symp. Rel. Bioact. Mater., (Controlled Release Society, Inc.) 14:1809-181 (1987).
D'Emanuele, et al., "An Investigation of the Effects of Ultrasound on Degradable Polyanhydride Matrices," Macromolecules 25:511-515 (1992).
Elias, "The Microscopic Structure of the Epidermis and Its Derivatives," Percutaneous Absorption: Mechanisms-Methodology-Drag Delivery (Bronaugh, R.L., Maibach, H., Editors, Marcel Dekker, New York,) 1-12 (1989).
Flynn, G. L., "Mechanism of Percutaneous Absorption from Physiochemical Evidence," Percutaneous Absorption: Mechanisms-Methodology-Drug Delivery (Bronaugh, R.L., Maibach, H., Editors, Marcel Dekker, New York) 27-51 (1989).
Friedman, R. M., Interferons: A Primer,(Academic Press, New York, 1981).
Gaetner, W., "Frequency Dependence of Ultrasonic Cavitation," J. Acoust. Soc. Am. 26:977-980 (1954).
Ghanem et al., "The effects of ethanol on the transport of lipophilic and polar permeants across hairless mouse skin: Mehtods/validation of a novel approach," Int. J. Pharm. 78:137-156 (1992).
Grups and Frohmuller, "Cyclic Interferon Gamma Treatment of Patients with Metastic Renal Carcinoma," J. Med. 64(3):218-220 (1989).
Hansch and Leo, "Substituent Constants for Correlation Analysis in Chemistry and Biology" (1979).
Junginger, et al., "Visualization of Drug Transport Across Human Skin and the Influence of Penetration Enhancers," Drug Permeation Enhancement (Hsieh, D.S., Editors, Marcel Dekker, Inc. New York) 59-89 (1994).
Kasting, et al., "Prodrugs for Dermal Delivery: Solubility, Molecular Size, and Functional Group Effects," Prodrugs: Topical and Ocular Delivery Sloan, ed. (Marcel Dekker, NY 1992) 117-161.
Kost and Langer, "Ultrasound-Mediated Transdermal Drug Delivery," Topical Drug Bioavailability Bioequivalence and Penetration (Maibach, H.I., Shah, V.P., Editors, Plenum Press, New York) 91-104 (1993).
Kost, et al., "Ultrasound Effect on Transdermal Drug Delivery," (Ben Gurion University Dept. of Chem. Engineering, Beer Sheva Israel) (MIT, Dept. of Appliced Biological Sciences, Cambridge, MA) CRS Aug. 1986.
Krall, L.P., World Book of Diabetes in Practice (Editors, Elsvier, 1988).
Lee, V. H. L., et al., "Protease Inhibition as an Additional Mechanism for the Nasal Absorption Enhancement Effect of Sodium Taurodihydrofusidate," Proceed. Intern. Symp. Control Rel. Bioact. Mater 14:55-56 (1987).
Lee, V. H. L., et al., "Nasal Peptide and Protein Absorption Promoters: Aminopeptides Inhibition as a Predictor of Absorption Enhancement Potency of Bile Salts," Proceed. Intern. Symp. Control Rel. Bioact. Mater 14:53-54 (1987).
Levy, et al., "Effect of Ultrasound on Transdermal Drug Delivery to Rats and Guinea Pigs," J. Clin. Invest. k 83:2074-2078 (1989).
Liu, et al., "Cotransport of Estradiol and Ethanol Through Humsn Skin In Vitro: Understanding the Permeant/Enhancer Flux Relationship," Pharmaceutical Research 8:938-944 (1991).
Liu, et al., "Experimental Approach To Elucidate the Mechanism of Ultrasound-Enhanced Polymer Erosin and Release of Incorporateed Substances," Macromolecules 25:123-128 (1992).
Machluf and Kost, "Ultrasonically enhanced transdermal drug delivery. Experimental approaches to elucidate the mechansim," J. Biomater. Sci. Polymer Edn. 5:147-156 (1993).
Malk, et al., "Oleic Acid Concentration and Effect in Human Stratum Corneum: Non-Invasive Determination by Attenuated Total Reflectance Infrared Spectroscopy In Vivo," J. Controlled Res. 12:67-75 (1990).
Mitragotri, et al., "Ultrasound-Me
Blankschtein Daniel
Langer Robert S.
Mitragotri Samir S.
Bawa Raj
Massachusetts Institute of Technology
LandOfFree
Transdermal protein delivery using low-frequency sonophoresis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transdermal protein delivery using low-frequency sonophoresis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transdermal protein delivery using low-frequency sonophoresis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-872997