Transdermal patch incorporating a polymer film incorporated with

Details Transdermal patch incorporating a polymer film incorporated with Transdermal patch incorporating a polymer film incorporated with

1997-10-21

2000-01-04

Brouillette, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, 427 231, A61F 1302

Patent

active

060107154

ABSTRACT:
Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer and a monolithic carrier layer formed from a melt blend of an active ingredient with a thermoplastic matrix polymer without first dissolving or suspending the polymer or active ingredient in a solvent therefor, so that the carrier layer is substantially free of residual solvent, wherein the thermoplastic matrix polymer has a melt temperature between about 170.degree. C. and about 200.degree. C. and is selected from polyether block amides, ethylene methacrylic acid copolymers, ethylene acrylic acid copolymers, copolymers of polyether prepolymers with polybutylene terephthalate, copolymers of polyether prepolymers with polyisobutylene terephthalate and polyether polyurethanes, the active ingredient is heat stable at the melt temperature of the matrix polymer and is selected from active agents, active agent enhancers and mixtures thereof, and the laminate is provided with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto. Methods for assembling the device are also disclosed.

REFERENCES:
patent: 4710191 (1987-12-01), Kwiatek
patent: 4839174 (1989-06-01), Baker
patent: 4840796 (1989-06-01), Sweet
patent: 4908213 (1990-03-01), Govil
patent: 4943435 (1990-07-01), Baker
patent: 5006342 (1991-04-01), Cleary
patent: 5023084 (1991-06-01), Chien
patent: 5126144 (1992-06-01), Jaeger

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