Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1988-03-04
1989-03-21
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424449, 424448, 424485, 424486, 424484, A61K 3174
Patent
active
048141682
ABSTRACT:
A dermal compositon comprising a drug, a multi-polymer of vinyl acetate, polyethylene and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber is, respectively, about 1:1 to about 10:1 and more preferably 1:1 to 5:1 and more preferably 3:1. The dermal composition can optionally contain a crosslinking agent, tackifiers, penetration enhancers and other ingredients known for use in adhesives for the transdermal delivery of drugs. The dermal compositions can be produced by a variety of methods known in the preparation of drug containing adhesive preparations including the homogenous mixing of the multi-polymer, drug and optional crosslinking agent and additional ingredients in aqueous solution followed by removal of excess water.
REFERENCES:
patent: 4144317 (1979-03-01), Higuchi et al.
patent: 4421737 (1988-12-01), Ito et al.
patent: 4668232 (1987-05-01), Wolff et al.
patent: 4743249 (1988-05-01), Loveland
Air Products and Chemicals, Inc., Technical Brochures for AIRFLEX.RTM. 400.TM. (1979), p. 3.
U.S.I. Chemicals "Adhesives and Coating Manual" (unknown date).
Leeson Dorothy J.
Questel John M.
Sablotsky Steven
Horne L. R.
Meloy Sybil
Noven Pharmaceuticals Inc.,
Page Thurman K.
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