Transdermal multipolymer drug delivery system

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only

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Details

424449, 424448, 424485, 424486, 424484, A61K 3174

Patent

active

048141682

ABSTRACT:
A dermal compositon comprising a drug, a multi-polymer of vinyl acetate, polyethylene and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber is, respectively, about 1:1 to about 10:1 and more preferably 1:1 to 5:1 and more preferably 3:1. The dermal composition can optionally contain a crosslinking agent, tackifiers, penetration enhancers and other ingredients known for use in adhesives for the transdermal delivery of drugs. The dermal compositions can be produced by a variety of methods known in the preparation of drug containing adhesive preparations including the homogenous mixing of the multi-polymer, drug and optional crosslinking agent and additional ingredients in aqueous solution followed by removal of excess water.

REFERENCES:
patent: 4144317 (1979-03-01), Higuchi et al.
patent: 4421737 (1988-12-01), Ito et al.
patent: 4668232 (1987-05-01), Wolff et al.
patent: 4743249 (1988-05-01), Loveland
Air Products and Chemicals, Inc., Technical Brochures for AIRFLEX.RTM. 400.TM. (1979), p. 3.
U.S.I. Chemicals "Adhesives and Coating Manual" (unknown date).

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