Transdermal formulations for administering prazosin

Details Transdermal formulations for administering prazosin Transdermal formulations for administering prazosin

1993-03-10

1997-11-18

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424448, 514946, 514947, A61F 1300

Patent

active

056885245

ABSTRACT:
Prazosin is formulated in solution with a akin permeation enhancer composition of: a sulfhydryl-containing compound, a fatty acid eater, and a polar solvent for transdermal administration to treat hypertension or benign prostatic hypertrophy. The formulation is employed in the form of a skin patch comprising (a) an impermeable backing layer, (b) a reservoir of the prazosin-enhancer solution, (c) a porous support member that retains the solution but is not a permeation barrier to the solution, a peripheral adhesive layer for affixing the patch to the skin, and a release liner layer.

REFERENCES:
patent: 4762851 (1988-08-01), Alexander et al.
patent: 4820720 (1989-04-01), Sanders et al.
patent: 4847250 (1989-07-01), Alexander et al.
patent: 4970206 (1990-11-01), Alexander et al.
patent: 5118845 (1992-06-01), Peck et al.
patent: 5474783 (1995-12-01), Miranda
Katz et al., "Enhanced skin permeation of Prazosin by transcutol-oleic acid mixture" Proceed. Intern. Symp. Control. Rel. Bioact. Mater., Controlled Release Society, Inc., (1991) 18:533-534.
Tenjarla, S.N., "Transdermal drug delivery of Prazosin" Pharm. Res. (1990) 7(9):S-189 (abstract No. PDD7312).

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