Transdermal drug delivery system

Details Transdermal drug delivery system Transdermal drug delivery system

1993-12-30

1995-11-14

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424447, 424448, 424489, 604 41, A61F 1300

Patent

active

054664659

ABSTRACT:
In a transdermal drug delivery system, encapsulation material used to coat drug granules controls the release of an active ingredient. The active ingredient is released into a water retaining matrix, which acts as a reservoir, and transdermal drug penetration is driven by the resulting concentration gradient. The delivery system is enclosed in a patch comprising a composite shell, which acts as an occlusive covering when attached to skin, thus enhancing the hydration of the skin area and fostering absorption of the drug. Visible change indicators incorporated into the system provide indicators at significant "landmarks" in the lifetime of the patch. Microcapsules used for the indicator may be formulated so that the penetration of moisture effects a color change at a time when the active ingredient is almost exhausted. This feature alerts to the user to the need for application of a replacement patch.

REFERENCES:
patent: 4314557 (1982-02-01), Chandrasekaren
patent: 4379454 (1983-04-01), Campbell et al.
patent: 4409206 (1983-10-01), Stricker
patent: 4439199 (1984-03-01), Amkraut et al.
patent: 4460372 (1984-07-01), Campbell et al.
patent: 4484923 (1984-11-01), Amkraut et al.
patent: 4597961 (1986-07-01), Etscorn
patent: 4624665 (1986-11-01), Nuwayser
patent: 4645502 (1987-02-01), Gale et al.
patent: 4666441 (1987-05-01), Andriola et al.
patent: 4690683 (1987-09-01), Chien et al.
patent: 4708716 (1987-11-01), Sibalis
patent: 4725263 (1988-02-01), McNichols et al.
patent: 4736866 (1988-04-01), Leder et al.
patent: 4743249 (1988-05-01), Loveland
patent: 4749574 (1988-06-01), Ueda et al.
patent: 4781924 (1988-11-01), Lee et al.
patent: 4824676 (1989-04-01), Bodor
patent: 4837027 (1989-06-01), Lee et al.
patent: 4877612 (1989-10-01), Berger et al.
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 4911707 (1990-03-01), Heiber
patent: 4917688 (1990-04-01), Nelson
patent: 4946787 (1990-08-01), Eppstein et al.
patent: 4956355 (1990-10-01), Prendergast
patent: 4963367 (1990-10-01), Ecanow
patent: 4973708 (1990-11-01), Digenis et al.
patent: 4994278 (1991-02-01), Sablotsky et al.
patent: 5003098 (1991-03-01), Siren et al.
patent: 5008111 (1991-04-01), Bodor
patent: 5032402 (1991-07-01), Digenis et al.
patent: 5049386 (1991-09-01), Eppstein et al.
patent: 5050612 (1991-09-01), Matsumara
patent: 5149538 (1992-09-01), Granger et al.
patent: 5166219 (1992-11-01), Katz
patent: 5194451 (1993-03-01), Katz
patent: 5208036 (1993-05-01), Eppstein et al.
patent: 5223261 (1993-06-01), Nelson et al.
patent: 5230897 (1993-07-01), Griffin et al.
patent: 5230898 (1993-07-01), Horstmann et al.
patent: 5234690 (1993-10-01), Chiang et al.

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