Transdermal drug delivery process

Details Transdermal drug delivery process Transdermal drug delivery process

1996-03-12

1997-12-23

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424448, 604 20, A61F 1300, A61N 130

Patent

active

057004811

ABSTRACT:
A calcitonin, its derivative or a salt thereof is transdermally delivered by iontophoresis in which a substantially constant voltage in the range of 3 to 20 V is applied at an electric current of 0.05 to 0.5 mA/cm.sup.2. In this process, the calcitonin can be delivered transdermally with a higher absorptivity by applying a higher voltage for a short period (at a voltage of about 6 to 14 V for about 5 to 15 minutes) in the initial stage of the voltage application, and then applying a lower voltage for a long period (at a voltage of about 3 to 9 V for about 30 to 40 minutes).

REFERENCES:
patent: H1160 (1993-04-01), Maulding et al.
patent: 5250022 (1993-10-01), Chien

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