Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1994-10-13
1997-03-11
Dean, Ralph H.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424449, 428156, 6048901, A61F 1302, A61L 1500
Patent
active
RE0354740
ABSTRACT:
This invention relates to an improved transdermal drug delivery device for the controlled transdermal delivery of amino-functional drugs. The improvement resides in providing the device with a silicone pressure-sensitive adhesive layer which has been chemically treated to reduce the silicon-bonded hydroxyl content of the pressure-sensitive adhesive composition to render the adhesive layer resistant to loss of tack and preserve the instant adherence of the device to the skin of a wearer during storage and while the device is being worn. Preferably, the composition used comprises a silicon-bonded hydroxyl radical containing resinous copolymer of R.sub.3 SiO.sub.1/2 units and SiO.sub.4/2 units and a polydiorganosiloxane which have been chemically treated with R.sub.3 SiO.sub.1/2 units where R is preferably a hydrocarbon radical such as a methyl group to reduce the silicon-bonded hydroxyl content of the adhesive and thereby its sensitivity to amino-functional drugs.
REFERENCES:
patent: 2736721 (1956-02-01), Dexter
patent: 2814601 (1957-11-01), Currie et al.
patent: 2857356 (1958-10-01), Goodwin
patent: 3528940 (1970-09-01), Modic
patent: 3731683 (1973-05-01), Zaffaroni
patent: 3797494 (1974-03-01), Zaffaroni
patent: 3929704 (1975-12-01), Horning
patent: 3983298 (1976-09-01), Hahn et al.
patent: 4031894 (1977-06-01), Urguhart et al.
patent: 4255316 (1981-03-01), Blizzard
patent: 4309520 (1982-01-01), Blizzard
patent: 4336243 (1982-06-01), Sanvordeker et al.
patent: 4417042 (1983-11-01), Dziark
patent: 4460371 (1984-07-01), Abber
patent: 4588580 (1986-05-01), Gale et al.
One page memo "To: All Adhesives Customers" From: S. Michael John, Silicone Products Division, General Electric Company Waterford, NY dated Aug. 1983 containing the following data sheets (2 pages each): CDS-4131, SRC 18, PSA 518, PSA 529, PSA 590, PSA 595, PSA 596, PSA 6573, PSA 6574, CDS-4138.
Chemical Abstracts, vol. 88, 1978, pp55, Abstract No. 88:122452m Poly(organosiloxanes). Karlin, A. V.; Lobkov, V. D.; Andrianov, K. A.; Petrova, I. M.; Vasil'eva, N. A.; Trofimov, V. M.; U.S.S.R.
Metevia Virgil L.
Woodard John T.
Dean Ralph H.
Dow Corning Corporation
Severance Sharon K.
LandOfFree
Transdermal drug delivery devices with amine-resistant silicone does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transdermal drug delivery devices with amine-resistant silicone , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transdermal drug delivery devices with amine-resistant silicone will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-435304