Transdermal drug delivery by electroincorporation of vesicles

Details Transdermal drug delivery by electroincorporation of vesicles Transdermal drug delivery by electroincorporation of vesicles

1994-09-22

1995-11-07

Cohen, Lee S.

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

424449, 4284022, A61K 966, A61N 130, A61F 1300

Patent

active

054643864

ABSTRACT:
A method of transdermal molecular delivery comprises the steps of encapsulating molecules to be delivered in a vesicle, contacting a selected area of a tissue surface with a solution of the vesicles, and applying a pulsed electric field of sufficient amplitude to induce dielectric breakdown of the stratum corneum and to induce transport of the intact vesicle through the pores in the stratum corneum into the underlying tissue to enable diffusion of molecules into the tissue.

REFERENCES:
patent: 4921757 (1990-05-01), Wheatley et al.
patent: 5149539 (1992-09-01), Ledger et al.
patent: 5160741 (1992-11-01), Cormier et al.
patent: 5312325 (1994-05-01), Sibalis

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