Transdermal delivery system for polynucleotides

Details Transdermal delivery system for polynucleotides Transdermal delivery system for polynucleotides

2005-01-25

2011-10-18

Sirmons, Kevin C (Department: 3767)

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

C604S500000

Reexamination Certificate

active

08041421

ABSTRACT:
A system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and methods of use thereof employ an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.

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