Transdermal delivery system for delivering nitroglycerin at high

Details Transdermal delivery system for delivering nitroglycerin at high Transdermal delivery system for delivering nitroglycerin at high

1985-05-03

1986-10-07

Yasko, John D.

Surgery

Controlled release therapeutic device or system

Osmotic or diffusion pumped device or system

424 28, 514509, 514964, A61K 900

Patent

active

046156992

ABSTRACT:
A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 .mu.g/cm.sup.2 hr and preferably in the range of 50-150 .mu.g/cm.sup.2 hr. Ethanol delivered at a rate of from 250-500 .mu.g/cm.sup.2 hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 11% and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure.

REFERENCES:
patent: 4201211 (1980-05-01), Chandrasekaran et al.
patent: 4294820 (1981-10-01), Keith et al.
patent: 4346709 (1982-08-01), Schmitt
patent: 4568343 (1986-02-01), Leeper et al.

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