Transdermal delivery system for delivering nitroglycerin at high

Details Transdermal delivery system for delivering nitroglycerin at high Transdermal delivery system for delivering nitroglycerin at high

1986-06-02

1987-07-21

Yasko, John D.

Surgery

Controlled release therapeutic device or system

Osmotic or diffusion pumped device or system

A61K 900

Patent

active

046815848

ABSTRACT:
A high flux transdermal nitroglycerin therapeutic system is disclosed which is capable of delivering nitroglycerin through intact human skin at rates of 40 .mu.g/cm.sup.2 hr and preferably in the range of 50-150 .mu.g/cm.sup.2 hr. Ethanol delivered at a rate of from 250-500 .mu.g/cm.sup.2 hr is employed as a permeation enhancer for the nitroglycerin and a rate controlling membrane formed from ethylene vinyl acetate having a vinyl acetate content greater than 11% and preferably between 12-18% provides the appropriate rate control for both the drug and the permeation enhancer. This system is suitable for use in treatment of angina pectoris and congestive heart failure.

REFERENCES:
patent: 4615699 (1986-10-01), Gale et al.

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