Transdermal delivery of the eutomer of a chiral drug

Details Transdermal delivery of the eutomer of a chiral drug Transdermal delivery of the eutomer of a chiral drug

1993-11-08

1999-03-16

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514457, 514626, 514648, 514654, 514947, 424449, 424486, A61K 3140, A61K 3135, A61K 3116, A61K 31135

Patent

active

058831150

ABSTRACT:
A pharmaceutical composition of the eutomer of a chiral drug is disclosed whereby the eutomer has a clearance value greater than that of the racemic mixture of the chiral drug. The pharmaceutical compositions of the present invention allow the delivery of therapeutically effective levels of drugs at doses much lower than would be required when the drug is delivered by conventional injection methods.

REFERENCES:
patent: 4089969 (1978-05-01), Muchowski et al.
patent: 4668232 (1987-05-01), Cordes et al.
patent: 4690683 (1987-09-01), Chien et al.
patent: 4818541 (1989-04-01), Sanderson
patent: 4822617 (1989-04-01), Panoz
patent: 4927854 (1990-05-01), Sunshine et al.
patent: 4940586 (1990-07-01), Cheng et al.
patent: 4940761 (1990-07-01), Davis
patent: 4983395 (1991-01-01), Chang et al.
patent: 4992445 (1991-02-01), Lawter et al.
patent: 5049386 (1991-09-01), Eppstein et al.
patent: 5091182 (1992-02-01), Ong et al.
patent: 5114946 (1992-05-01), Lawter et al.
patent: 5124157 (1992-06-01), Colley et al.
patent: 5132119 (1992-07-01), Lee
patent: 5304379 (1994-04-01), Cormier et al.
Stinson, S.C., "Chiral Drugs" C&EN pp. 46-79 (Sep. 28, 1992).
Knadler, M.P., et al. (1992) "Stereoselective Disposition of Flurbiprofen in Normal Volunteers" Br. J. Clin. Pharmac. 33:369-375.
Mroszczak, E., et al. (1991) Clin. Pharmacology & Therapeutics 49:126.
Campbell, D.B. (1990) "Stereoselectivity in Clinical Pharmacokinetics and Drug Development" European Journal of Drug Metabolism and Pharmacokinetics 15(2):109-125.
Rowland, M., et al. (1989) Clinical Pharmacokinetics: Concepts and Applications, 2nd Ed. pp. 19-25.
Smith, D.F. (1989) "The Stereoselectivity of Drug Action" Pharmacology & Taxicology 65:321-331.
Jamali, F., et al. (1989) "Enantioselectivity Aspects of Drug Action and Disposition: Therapeutic Pitfalls" Journal of Pharmaceutical Sciences 78(9):695-714.
Ariens, E.J., et al. "Stereoselectivity of Bioactive Xenobiotics" Biochemical Pharmacology 37(1):9-18, 1989.
Guzman, A., et al. (1986) "Absolute Configuration of Active Enantiomer of Keterolac" J. Med. Chem. 29:589-591.
Drayer, D.E. (1986) "Pharmacodynamic and Pharmacokinetic Differences Between Drug Enantiomers in Humans: An Overview" Clinical Pharmacology & Therapeutics 40(2):125-133.
Baker, R. (1987) Controlled Release of Biologically Active Agents, John Wiley & Sons, New York, pp. 4-10.

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