Transdermal delivery of estradiol and process for manufacturing

Details Transdermal delivery of estradiol and process for manufacturing Transdermal delivery of estradiol and process for manufacturing

1996-01-11

1998-01-06

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61F 1300

Patent

active

057051852

ABSTRACT:
The present invention relates to a transdermal delivery device for estradiol where the metabolic degradation of estradiol to estrone during permeation is inhibited by another substance in the transdermal delivery device. The transdermal device also includes a compound for enhancing the rate of estradiol permeation. The transdermal delivery device containing the inhibitor and enhancer can also be used to simultaneously deliver both estradiol and a progestin at therapeutic rates.

REFERENCES:
patent: 4379454 (1983-04-01), Campbell et al.
patent: 4537776 (1985-08-01), Cooper
patent: 4764381 (1988-08-01), Bodor et al.
patent: 4814168 (1989-03-01), Sablotsky et al.
patent: 4855294 (1989-08-01), Patel et al.
patent: 4863970 (1989-09-01), Patel et al.
patent: 4885174 (1989-12-01), Bodor et al.
patent: 4954487 (1990-09-01), Cooper et al.
patent: 4973468 (1990-11-01), Chiang et al.
patent: 4994267 (1991-02-01), Sablotsky
patent: 5023084 (1991-06-01), Chien et al.
Cooper, E.R., "Increased Skin Permeability for Lipophilic Molecules," Journal Pharmaceutical Sciences, 73(8):1153-1156, (1984).
Idson, B., "Dermatological Emulsions," Cosmetics & Toiletries, Creams and Lotions, 95:59-62 (Mar. 1980).
Mollgaard et al., "Vehicle Effect On Topical Drug Delivery" II. Concurrent skin transport of drugs and vehicle components, Acta Pharm. Suec. 20:443-450 (1983).
Biological Abstracts, vol. 88, nr. 1, 1989, abstract nr 9062, Philadephia, PA, US; goodman et al.: "Action of penetration enhancers on skin as assessed by the permeation of model drug 5-fluorouracil and estradiol", & J. Invest. Darmatol. 91(4): 323-327, 1988.
Proceed. Intern. Symp. Control. Rel.Bioact. Mater. 14 (1987) pp. 101-102.

Affiliated with

Also associated with

Rating

Transdermal delivery of estradiol and process for manufacturing does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transdermal delivery of estradiol and process for manufacturing , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transdermal delivery of estradiol and process for manufacturing will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2326707