Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-08-04
1998-09-29
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
604 20, 604 23, 604 49, 604304, 6048921, 128 24, 128632, 128633, 128760, 128761, 424450, A61K 3828, A61N 130, A61M 3700, A61M 3100
Patent
active
058145990
ABSTRACT:
Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).
REFERENCES:
patent: 3551554 (1970-12-01), Herschler
patent: 3711602 (1973-01-01), Herschler
patent: 3711606 (1973-01-01), Herschler
patent: 4002221 (1977-01-01), Buchalter
patent: 4127125 (1978-11-01), Takemoto et al.
patent: 4144646 (1979-03-01), Takemoto et al.
patent: 4176664 (1979-12-01), Kalish
patent: 4249531 (1981-02-01), Hiller et al.
patent: 4280494 (1981-07-01), Cosgrove, Jr. et al.
patent: 4309989 (1982-01-01), Fahim
patent: 4372296 (1983-02-01), Fahim
patent: 4537776 (1985-08-01), Cooper
patent: 4557943 (1985-12-01), Rosler et al.
patent: 4563184 (1986-01-01), Korol
patent: 4646725 (1987-03-01), Moasset
patent: 4698058 (1987-10-01), Greenfeld et al.
patent: 4767402 (1988-08-01), Kost et al.
patent: 4780212 (1988-10-01), Kost et al.
patent: 4820720 (1989-04-01), Sanders et al.
patent: 4821740 (1989-04-01), Tachibana et al.
patent: 4834978 (1989-05-01), Nuwayser
patent: 4855298 (1989-08-01), Yamada et al.
patent: 4860058 (1989-08-01), Kobayashi et al.
patent: 4863970 (1989-09-01), Patel et al.
patent: 4953565 (1990-09-01), Tachibana et al.
patent: 5006342 (1991-04-01), Cleary et al.
patent: 5007438 (1991-04-01), Tachibana et al.
patent: 5016615 (1991-05-01), Driller
patent: 5076273 (1991-12-01), Schoendorfer et al.
patent: 5115805 (1992-05-01), Bommannan et al.
patent: 5139023 (1992-08-01), Stanley et al.
patent: 5140985 (1992-08-01), Schroder et al.
patent: 5171215 (1992-12-01), Flanagan
patent: 5197946 (1993-03-01), Tachibana
patent: 5231975 (1993-08-01), Bommannan et al.
patent: 5267985 (1993-12-01), Shimada et al.
patent: 5315998 (1994-05-01), Tachibana et al.
patent: 5323769 (1994-06-01), Bommannan et al.
patent: 5386837 (1995-02-01), Sterzer
patent: 5401237 (1995-03-01), Tachibna et al.
patent: 5405614 (1995-04-01), D'Angelo et al.
patent: 5415629 (1995-05-01), Henley
patent: 5421816 (1995-06-01), Lipkovker
patent: 5445611 (1995-08-01), Eppstein et al.
patent: 5458140 (1995-10-01), Eppstein et al.
patent: 5580575 (1996-12-01), Unger et al.
Egorov, E.A. et al., "Use of the Variants of the Pharmacophysical Influence in Ophthalmology", 102 Ophthalmology Journal #2 (1992).
Eppstein, D.A. et al., "Applications of Liposome Formulations for Antimicrobial/Antiviral Therapy" Liposomes as Drug Carriers 311, 315 (G. Gregoriadis ed. 1988).
Eppstein, D.A., "Medical Utility of Inteferons: Approaches to Increasing Therapeutic Efficacy" 7 Pharmacy International 195-198 (1986).
Eppstein, D.A. et al., "Alternative Delivery Systems for Peptides and Proteins as Drugs" 5 CRC Reviews in Therapeutic Drug Carrier Systems 99, 125 (1988).
Loshilov, V.I. et al., "Research of the Technological Process of Ultrasound Treatment of Infected Wounds" (1976).
Ulashik, V.S. et al., Ultrasound Therapy (Minsk, Belarus 1983).
Remington Phamaceutical Sciences, pp. 267-272, 1600-1606, 1614, 1690-1693, 1990.
D.A. Jones, Polymeric Carriers for Active Agents in Transdermal and Related Drug Delivery Systems, Noyes Data Corporation, pp. 223-279, 1984.
Schreier, et al., Liposomes and Niosomes as Topical Drug Carriers: Dermal and Transdermal Drug Delivery, Journal of Controlled Release, vol. 30, pp. 1-15, 1994.
Kamath, et al., Biodegradable Hydrogels in Drug Delivery, Advanced Drug Delivery Reviews, vol. 11, pp. 59-84, 1993.
Domb, et al., Polyanhydrides--Synthesis and Characterization, Advances in Polymer Science, vol. 107 pp. 93-141, 1993.
Agrawal, et al., the Effects of Ultrasound Irradiation on a Biodegradable 50-50% Copolymer of Polylactic and Polyglycolic Acids, Journal of Biomedical Research, vol. 28, No. 8, pp. 851,859, Aug. 1994.
Smith, et al., Percutaneous Penetration Enhancers, I.E.C., Lyon, France, pp. 369-382, 1995.
Bhat, et al., Optimization of Delivery of Betamethasone-dipropionate from Skin Preparation, Indian Drugs, 32/5, pp. 211-5, pp. 211-214, 1995.
Apfel, R. F., "Possibility of Microcavitation from Diagnostic Ultrasound," IEEE Trans. Ultrason. Ferroelectrics Freq. Control UFFC-33:139-142 (1986).
Aungst, et al., "Contributions of Drug Solubilization, Partitioning, Barrier Disruption, and Solvent Permeation to the Enhancement of Skin Permeation of Various Compounds with Fatty Acids and Amines," Pharm. Res. 7:712-718 (1990).
Barry, "Mode of Action of Penetration Enhancers in Human Skin," J. Controlled Rel. 6:85-97 (1987).
Bommer, et al., "Subcutaneous Frythropoeitin," Lancet 406 (1988).
Burnette, R. R., "Iontophoresis," Transdermal Drug Delivery Developmental Issues and Research Initiatives (Hadgraft and Guy, Editors, Marcel Dekker, 247-291, 1989).
Cleary, Gary W., "Transdermal Controlled Release Systems,"Medical Applications of Controlled Release (Langer and Wise, Editors, CRC Press 203-251, 1984).
Clegg and Vaz, "Translational diffusion of proteins and lipids in artificial lipid bilayer membranes. A comparison of experiment with theory," Progress in Protein-Lipid Interactions Watte, ed. (Elsvier, NY 1985) Chapter 5:173-229.
Davis, J., et al., "Characterization of Recombinant Human Erythropoietin Produced in Chinese Hamster Ovary Cells," Biochemistry 26:2633-2638 (1987).
Ebert, et al., "Transbuccal Absorption of Diclofenac Sodium in a Dog Model," Controlled Release Technology Pharmaceutial Application (Lee, et al. Editors, American Chemical Society)310-321 (1987).
Eggerth, et al., "Evaluatin of Hamster Cheek Pouch as a Model for Buccal Absorption," Proceed. Intern. Symp. Rel. Bioact. Mater.,(Controlled Release Society, Inc.) 14:180-181 (1987).
D'Emanuele, et al., "An Investigation of the Effects of Ultrasound on Degradable Polyanhydride matrices," Macromolecules 25:511-515 (1992).
Elias, "The Microscopic Structure of the Epidermis and Its Derivatives," Percutaneous Absorption: Mechanisms- Methodology-Drag Delivery (Bronaugh, R. L., Maibach, H., Editors, Marcel Dekker, New York,) 1-12 (1989).
Flynn, G. L., "Mechanism of Percutaneous Absorption from Physicochemical Evidence," Percutaneous Absorption: Mechanisms-Methodology-Drug Delivery (Bronaugh, R. L., Maibach, H., Editors, Marcel Dekker, New York) 27-51 (1989).
Friedman, R. M., `Interfrons: A Primer`, (Academic Press, New York, 1981).
Gaertner, W., "Frequency Dependence of Ultrasonice Cavitation," J. Acoust. Soc. Am. 26:977-980 (1954).
Ghanem et al., "The effects of ehtanol on the transport of lipophilic and polar permeants across hairless moust skin: Methods/validation of a novel approach," Int. J. Pharm. 78:137-156 (1992).
Grups and Frohmuller, "Cyclic Interferon Gamma Treatment of Patients with Metastatic Renal Carcinoma," J. Med. 64(3):218-220 (1989).
Junginger, et al., "Visualization of Drug Transport Across Human Skin and the Influence of Penetration Enhancers," Drug Permeation Enhancement (Hsieh, D.S., Editors, Marcel Dekker, Inc. New York) 59-89 (1994).
Kasting, et al., "Prodrugs for Dermal Delivery: Solubility, Molecular Size, and Functional Group Effects," Prodrugs: Topical and Ocular Delivery Sloan, ed. (Marcel Dekker, NY 1992) 117-161.
Kost and Langer, "Ultrasound-Mediated Transdermal Drug Delivery," Topical Drug Bioequivalence and Penetration (Maibach, H. I., Shah, V. P., Editors, Plenum Press, New York) 91-104 (1993).
Lee, V. H. L., et al., "Protase Inhibition as an Additional Mechanism for the Nasal Absorption Enhancement Effect of Sodim Taurodihydrofusidate," Proceed. Intern. Symp. Control. Rel. Bioact. Mater 14:55-56 (1987).
Lee, V. H. L., et al., "Nasal Peptide and Protein Absorption Promotors: Aminopeptidase Inhibition as a Predictor of Absorption Enhancement Potency of Bile Salts," Proceed. Intern. Symp. Control. Rel. Bioact. Mater 14:53-54 (1987).
Levy, et al., "Effect of Ultrasound on Transdermal Drug Delivery to Rats and Guinea
Blankschtein Daniel
Langer Robert S.
Mitragotri Samir S.
Harle Jennifer
Massachusetts Insitiute of Technology
Tsang Cecilia J.
LandOfFree
Transdermal delivery of encapsulated drugs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transdermal delivery of encapsulated drugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transdermal delivery of encapsulated drugs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-686255