Transdermal delivery of calcium channel blockers, such as nifedi

Details Transdermal delivery of calcium channel blockers, such as nifedi Transdermal delivery of calcium channel blockers, such as nifedi

1995-03-03

2000-08-22

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, 514946, A61F 1302

Patent

active

06106856&

ABSTRACT:
A transdermal formulation of dihydropyridine calcium antagonists and specifically nifedipine, nimodipine and nitrendipine. The calcium antagonists are dispersed in a mixed liquid. The mixed liquid comprises varying mole fractions of cis-oleic acid and dimethylisosorbide dispersed in a polypropylene glycol base.

REFERENCES:
patent: 4082881 (1978-04-01), Chen
patent: 4711904 (1987-12-01), Luzzi
patent: 4777047 (1988-10-01), Bauek
patent: 4789547 (1988-12-01), Song et al.

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