Transdermal delivery of (+) (2S,3S)-3-acetoxy-8-chloro-5-(2-dime

Details Transdermal delivery of (+) (2S,3S)-3-acetoxy-8-chloro-5-(2-dime Transdermal delivery of (+) (2S,3S)-3-acetoxy-8-chloro-5-(2-dime

1989-09-29

1991-03-26

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61F 1302

Patent

active

050027735

ABSTRACT:
A method for treating angina, epilepsy and hypertension by achieving vasodilation, anti-angina or anti-convulsant effect in a patient is described. The method involves transdermally administering to a patient in need of vasodilation or anti-convulsant effect the compound known as (+)(2S,3S)-acetoxy-8-chloro-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-meth oxyphenyl)-1,5-benzothiazepin-4-(5H)-one in an amount sufficient to achieve desired systemic vasodilation, anti-angina or anti-convulsant levels of the compound.

REFERENCES:
patent: 4777047 (1988-10-01), Bauer et al.
patent: 4879289 (1989-11-01), Zobrist et al.

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