Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1993-09-17
1996-01-09
Phelan, D. Gabrielle
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514691, 514944, 514946, 514947, 514969, 424443, 424446, A01N 3710
Patent
active
054829704
ABSTRACT:
Novel compositions comprising an antiandrogenic compound of the formula ##STR1## wherein R is COR.sub.1 wherein R.sub.1 is loweralkyl and a vehicle comprising a metabolism modulator and a polar organic solvent, and a method of controlling the membrane permeation and metabolism of the compound thereof are disclosed.
REFERENCES:
patent: 3472931 (1969-10-01), Stoughton
patent: 3551554 (1970-12-01), Herschler
patent: 3969516 (1976-07-01), Stoughton
patent: 3989816 (1976-11-01), Rajadhyaksha
patent: 4017641 (1977-04-01), DiGiulio
patent: 4202888 (1980-05-01), Eckert
patent: 4466971 (1984-08-01), Bouton
patent: 4684635 (1987-08-01), Orentreich
patent: 4783450 (1988-11-01), Fawzi
patent: 4788062 (1988-11-01), Gale
patent: 4788063 (1988-11-01), Fisher
patent: 4804541 (1989-02-01), Nichols
patent: 4808414 (1989-02-01), Peck
patent: 4810499 (1989-03-01), Nuwayser
patent: 4879119 (1989-11-01), Konno
patent: 4897269 (1990-01-01), Mezei
patent: 4900555 (1990-02-01), Cheng
Y. W. Cheung, A. Li Wan Po, W. J. Irwin--"Cutaneous Biotransformation as a Parameter in the Modulation of the Activity of Topical Corticosteroids," International Journal of Pharmaceutics, 26, 175-189 (1985).
A. D. Woolfson, D. F. McCafferty and K. E. McGowan, "The Metabolism of Amethocaine by Porcine and Human Skin Extracts: Influence on Percutaneous Anaesthesia," International Journal of Pharmaceutics, 62, 9-14 (1990).
R. O. Potts, S. C. McNeil, C. R. Desbonnet, and E. Wakshull, "Transdermal Drug Transport and Metabolism--The Role of Competing Kinetic Events," Pharmaceutical Research, 6, 119-124 (1989).
Henderson Norman L.
Kim Kwon H.
Koplowitz Barry
Hoechst-Roussel Pharmaceuticals Inc.
Phelan D. Gabrielle
Wittekind Raymond R.
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