Transdermal and trans-membrane delivery of drugs

Details Transdermal and trans-membrane delivery of drugs Transdermal and trans-membrane delivery of drugs

1989-12-08

1991-06-11

Sneed, Helen S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514431, 514450, A61K 3155

Patent

active

050232525

ABSTRACT:
The rate of absorption of drugs across skin and other body membranes such as mucous membranes and the blood brain barrier is enhanced by adding to the drug composition a compound which enhances the rate. This compound may be macrocyclic ester, diester, amide, diamide, amidine, diamidine, thioester, dithioester, thioamide, ketone or lactone. The macrocyclic ketone contains at least 12 carbon atoms.

REFERENCES:
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patent: 3921636 (1975-11-01), Zaffaroni
patent: 3964482 (1976-06-01), Gerstel et al.
patent: 3996934 (1976-12-01), Zaffaroni
patent: 4405616 (1983-09-01), Rajadhyaksha
patent: 4415563 (1983-11-01), Rajadhyadsha
patent: 4557934 (1985-12-01), Cooper
patent: 4590170 (1986-05-01), Akiyoshi et al.
patent: 4710497 (1987-12-01), Heller et al.
Jones, "Transdermal and Related Drug Delivery Systems", Noyes Data Corp. (U.S.A.), pp. 109-137, (1984).

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