Transdermal administration of short or intermediate half-life be

Details Transdermal administration of short or intermediate half-life be Transdermal administration of short or intermediate half-life be

1993-06-28

1995-01-03

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424447, 424448, A61F 1300

Patent

active

053784731

ABSTRACT:
Method and laminated composite for administering short or intermediate half-life benzodiazepines such as alprazolam or triazolam transdermally to treat conditions such as anxiety in the case of alprazolam and insomnia in the case of triazolam. The composite comprises an impermeable backing layer and a reservoir layer containing the benzodiazepine and a permeation enhancer combined with a solvent-based acrylic polymer adhesive with the amounts of benzodiazepine and enhancer being sufficient to cause the benzodiazepine to pass through the skin at a rate in excess of about one .mu.g/cm.sup.2 /hr.

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