Transdermal administration of short or intermediate half-life be

Details Transdermal administration of short or intermediate half-life be Transdermal administration of short or intermediate half-life be

1991-08-27

1993-07-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424447, 424448, 424449, A61F 1300

Patent

active

052251985

ABSTRACT:
Method and laminated composite for administering short or intermediate half-life benzodiazepines such as alprazolamine or triazolam transdermally to treat conditions such as anxiety in the case of alprazolam and insomnia in the case of triazolam. The composite comprises an impermeable backing layer and a reservoir layer containing the benzodiazepine and a permeation enhancer combined with a solvent-based acrylic polymer adhesive with the amounts of benzodiazepine and enhancer being sufficient to cause the benzodiazepine to pass through the skin at a rate in excess of about one .mu.g/cm.sup.2 /hr.

REFERENCES:
patent: 3987052 (1976-10-01), Hester, Jr.
patent: 4557934 (1985-12-01), Cooper
patent: 4973468 (1990-11-01), Chiang et al.
USP Drug Information for the Health Care Professional, 10th Edition, (1990) pp. 595-602.
Abernethy et al., J. Clin. Psychiatry (1983) 44(8, Sect. 2):3 pages total.
Smith et al., Psychopharmacology (1984) 84:452-456.
Shell et al., Cardiology (1986) 4(4):697-704.
Stahl et al., Psychopharmacology Bulletin (1985) 21(3):657-662.
Cho et al., J. Pharmaceutical Sciences (1983) 72(4):356-362.
Ormerod et al., British J. Dermatology (1989) 121:411-415.
Adams et al., Anal. Chem. (1984) 56(9):1590-1594.
Yalkowsky et al., J. Pharmaceutical Sciences (1983) 72(9):1014-1017.

Affiliated with

Also associated with

Rating

Transdermal administration of short or intermediate half-life be does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transdermal administration of short or intermediate half-life be, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transdermal administration of short or intermediate half-life be will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1688155