Transdermal administration of ropinirole and analogs thereof

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...

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424448, A61F 1300

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active

058075704

ABSTRACT:
Transdermal administration of certain indolone derivatives which are dopamine D.sub.2 agonists is described. The method involves treating an individual afflicted with Parkinson's disease by administering an indolone derivative, e.g., ropinirole base or a pharmaceutically acceptable ropinirole salt, through the skin or mucosal tissue, for a time period and at an administration rate effective to alleviate the symptoms of the disease. Pharmaceutical formulations and drug delivery systems for administering the drugs are provided as well.

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R.J. Eden et al., "Preclinical Pharmacology of Ropinirole (SK&F 101468-A) a Novel Dopamine D.sub.2 Agonist", Pharmacol. Biochem. & Behavior 38:147-154 (1991).

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