Transdermal administration of fentanyl and device therefor

Details Transdermal administration of fentanyl and device therefor Transdermal administration of fentanyl and device therefor

1984-07-23

1986-05-13

Kight, John

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 14, 424 16, 424 19, 424 22, 514316, 514329, 604896, 604897, 604 93, 604304, 604307, A01N 2524, A61K 970

Patent

active

045885800

ABSTRACT:
Transdermal delivery systems for delivery of fentanyl and its analgetically effective derivatives for extended periods of time are disclosed which deliver the base form of the drug at a rate of from 0.5 to 10 .mu.g/cm.sup.2 /hr for a substantial portion of their useful life. The systems can be from 5-100 cm.sup.2 in releasing surface and preferably employ an in-line amine resistant adhesive. Preferred rate controlled systems utilize an aqueous ethanolic gel to minimize drug content.

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patent: 4127127 (1978-11-01), Wong et al.
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patent: 4379454 (1983-04-01), Campbell et al.
patent: 4379789 (1983-04-01), Capetola et al.
Andrews et al, "Fentanyl-A Review ", Clinics in Anaesthesiology, vol. 1, No. 1, Apr. 1983, pp. 97-122.
Isaacs, "A Safer Way to Take Your Medicine", Parade Magazine, May 12, 1985, p. 8.
Sanders, "Improved Drug Delivery", Chem and Eng News, vol. 63, No. 13, Apr. 1, 1985, pp. 30-40, 44, 45, 47 and 48.
Rensberger, "`Designer Drugs` Skirt the Law", Mar. 14, 1985, Washington Post, pp. A1, A5.

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