Transdermal acrylic multipolymer drug delivery system

Details Transdermal acrylic multipolymer drug delivery system Transdermal acrylic multipolymer drug delivery system

1989-01-11

1991-02-19

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424484, 424485, 424486, 424448, 424449, A61K 3174

Patent

active

049942670

ABSTRACT:
A dermal composition comprising a drug, a multipolymer of ethylene-vinyl acetate, an acrylic polymer, and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber is, respectively, about 1:1 to about 10:1 and more preferably, 1:1 to 5:1 and more preferably 3:1. The dermal composition can optionally contain a crosslinking agent, tackifiers, penetration enhancers and other ingredients known for use in adhesives for the transdermal delivery of drugs. The dermal compositions can be produced by a variety of methods known in the preparation of drug containing adhesive preparations including the homogenous mixing of the multipolymer, drug and optional crosslinking agent and additional ingredients in solution or suspension or emulsion followed by removal of excess solvent.

REFERENCES:
patent: 4568343 (1986-02-01), Leeper et al.
patent: 4573996 (1986-03-01), Kwiatek et al.
patent: 4906475 (1990-03-01), Kim

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