Transdermal 2-(4-isobutylphenyl)-propionic acid medication and m

Details Transdermal 2-(4-isobutylphenyl)-propionic acid medication and m Transdermal 2-(4-isobutylphenyl)-propionic acid medication and m

1981-11-23

1985-11-26

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514786, 514947, A61K 3119

Patent

active

045555249

ABSTRACT:
An externally administrable pharmaceutical which contains an effective amount of 2-(4-isobutylphenyl)propionic acid in a base is obtained by drug dissolution in a mixture of C.sub.6-12 carboxylic acid triglycerides, glycerol monostearate-polyoxyethylene stearate mixture and polyoxyethylene-fatty acid esters. A cream is obtained by stirring this solution with an aqueous phase in the presence of heat.

REFERENCES:
patent: 4282216 (1981-08-01), Rovee et al.
patent: 4390520 (1983-06-01), Nagai et al.
Farmaceutico, 1982, A-108.
Boll. Chim. Farm., 119 (1980), p. 738, G. Bramati et al., "Release Drugs in Vitro from Different Dermatological Preparations".
Patent Abstracts of Japan, vol. 6, No. 7, 1/16/82, Nissan Kagaku Kogyo K.K., "Ketoprofen Composition for Rectum Administration".
Patent Abstracts of Japan, vol. 6, No. 250, 12/9/82, Kouwa Yakuhin Kogyo K.K., "Preparation of Ibuprofen Pharmaceutical".

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