Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1985-01-23
1986-07-01
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
514314, 514813, A61K 970, A61K 31465
Patent
active
045979618
ABSTRACT:
Percutaneous administration of nicotine in a dose approximating the dose delivered by a variety of nicotine-containing products, such as cigarettes, cigars, snuff and chewing tobacco, is carried out using an occlusive pad. The nicotine is delivered so as to mimic the pharmacological effects of nicotine provided by the conventional use of tobacco, and a therapeutic function is achieved by reducing or eliminating the need for the tobacco product. A suitable transdermal application pad comprises a reservoir for liquid nicotine base to be affixed to the skin in a variety of places. Due to the high lipid solubility and resultant high skin permeability of nicotine, vehicles or solvents are not generally needed to enhance dermal absorption.
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The Merck Index-Tenth Edition, 1983, Published by Merck & Co., Inc. Rahway, N.J., U.S.A., p. 935.
Drug Alcohol Dependence, 13 (1984), pp. 209-213 Elsevier Scientific Publishers Ireland Ltd.
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