Transcripts of the MHC class I HLA-G gene and their applications

Details Transcripts of the MHC class I HLA-G gene and their applications Transcripts of the MHC class I HLA-G gene and their applications

1995-03-17

1999-01-05

Jones, W. Gary

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

53038873, 53038875, 5303896, 530403, 5303871, 5303873, 5303879, 5303891, 4241561, 4241841, 4242781, 435343, 4353431, 435 71, 435 72, 435 79, 435 6, 436538, C07K 1300, C07K 1600, A61K 39395, G01N 3353

Patent

active

058564420

ABSTRACT:
Transcripts of the major histocompatibility complex (MHC) Class I HLA-G gene which are present in foetal trophoblasts and/or in adult circulating mono-nuclear cells, as well as methods of using these. Either the said transcripts comprise, in succession in the 5' to 3' direction: a fragment encoding the signal peptide (exon 1), a fragment encoding the .alpha.1 domain (exon 2), a fragment encoding the .alpha.2 domain (exon 3), a fragment encoding the transmembrane TM domain (exon 5), a fragment encoding the cytoplasmic domain (exon 6) and the 3' untranslated fragment (exon 8), which sequence is designated HLA-G4, or the said transcripts comprise intron 4.

REFERENCES:
Shukla, et al., Nucleic Acids Research, vol. 18, No. 8, (1990), p. 2189.
Ishitani, et al., Proceedings of the National Academy of Sciences of the USA, vol. 89, No. 9, (1992), pp. 3947-3951.
Geraghty, et al., Proceedings of the National Academy of Sciences of the USA, vol. 84, No. 24, (1987), pp. 9145-9149.
Geraghty, Current Opinion in Immunology, vol. 5, No. 1 (1993), pp. 3-7.
Geraghty, et al., The FASEB Journal, vol. 7, No. 4 (1990), p. A2216.
Talmadge et al. Advanced Drug Delivery Reviews 10: 247-299, 1993.
Ellis et al. J. of Immunology 144: 731-735, 1990.

Affiliated with

Also associated with

Rating

Transcripts of the MHC class I HLA-G gene and their applications does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transcripts of the MHC class I HLA-G gene and their applications, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transcripts of the MHC class I HLA-G gene and their applications will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-863427