Transcriptional regulatory factor

Details Transcriptional regulatory factor Transcriptional regulatory factor

2007-05-08

2007-05-08

Wax, Robert A. (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S252300, C435S254110, C435S320100, C435S325000, C536S023500

Reexamination Certificate

active

10754342

ABSTRACT:
BLAST search was done on the EST database by using various nucleotide sequences encoding known bromodomain motifs to discover several ESTs likely encoding bromodomain genes. Next, testicular cDNAs were PCR cloned by using primers designed based on the sequence of EST (W17142), which is one of the ESTs discovered above. By using the thus obtained PCR product as a probe, the testicular library was screened. The obtained cDNA clone was used as a probe to re-screen the testicular cDNA library, thereby successfully isolating a full-length cDNA corresponding to EST (W17142). The protein encoded by the thus isolated cDNA had, in addition to the bromodomain, several regions and domains conserved in transcription regulatory factors. Moreover, the protein interacted with proteins associated with the chromatin-mediated transcriptional regulatory mechanism and a transcription co-activator.

REFERENCES:
patent: 1 033 401 (2000-09-01), None
patent: 1 033 401 (2000-09-01), None
patent: WO 99/10363 (1999-03-01), None
patent: WO 99/53045 (1999-10-01), None
patent: WO 00/21991 (2000-04-01), None
patent: WO 00/55320 (2000-09-01), None
Popi Syntichaki et al. Nature, 404:414-417, 2000.
Raymond H. Jacobson et al.: Science, 228: 1422-1425, 2000.
Tony Kouzarides: EMBO J, 19:1176-1179, 2000.
Bowser R, Giambrone A, Davies P. FACI, a novel gene identified with the monoclonal antibody Alz50, is developmentally regulated in human brain. Dev Neurosci. 1995; 17(1):20-37.
Georgakopoulos et al., “Histone acetyltransferase GCN5,” EMBL Database accession No. Q03330 (1993).
Hillier et al., “zb12c07.rl Soares—fetal—lung—NbHL19W Homo sapiens cDNA clone Image: 301826 5′ similar to SW: GCN5—Yeast Q03330 Transcriptional Activator GCN5,” NCBI Database accession No. W17142 (1996).
Hillier et al., “zj2lhl2.sl Soares fetal liver spleen 1NFLS s1 Homo sapiens cDNA clone 450983 3′ similar to TR: Q12830 Fetal ALZ-50-Reactive Clone 1,” EMBL accession No. AA704421 (1998).
Hillier et al., “zr51a03.rl Soares NhHMPu S1 Homo sapiens cDNA clone 666892 5′ similar to SW: GCN5—Yeast Q03330 Transcriptional Activator GCN5,” EMBL Database accession No. AA236286 (1997).
Jones et al., “Identification and Characterization of BPTF, a Novel Bromodomain Transcription Factor,”Genomics, 63(1):35-39 (2000).
Seq Id No: 3139 of EP 1 033 401 A2, EMBL Database accession No. AAG03135 (2000).
Seq Id No: 7216 of EP 1 033 401 A2, EMBL Database accession No. AAC03141 (2000).

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