Transcriptional regulator

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Reexamination Certificate

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C530S350000

Reexamination Certificate

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10702148

ABSTRACT:
Genes each encoding a novel transcriptional regulator having a bromodomain have been successfully isolated from a human testis cDNA library using primers prepared based on an EST sequence found using the bromodomain sequence of the transcriptional regulator. These genes are structurally analogous to each other.

REFERENCES:
patent: 6596482 (2003-07-01), Jones
patent: 6727222 (2004-04-01), Jones
Colman, Research in Immunology, 145(1):33-36, 1994.
Dhalluin et al., “Structure and ligand a histone acetyltransferase bromodomain,” Nature, vol. 399, pp. 491-496, Jun. 3, 1999.
Haynes et al., “The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins,” Nucleic Acids Research, vol. 20, p. 2603, Apr. 2, 1992.
Ito et al., “AFC consists of two subunits, Acfl and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly,” Genes & Development, vol. 13, pp. 1529-1539, 1999.
Jones, M.H., “The bromodomain revisited,” Letters, pp. 151-153, 1997.
Lu et al., “A Novel Human Gene, WSTF, Is Deleted in Williams Syndrome,” Genomics, vol. 54, pp. 241-249, 1998.
Tamkun et al., “brhma: A Regulator of Drosophila Homeotic Genes Structurally Related to the Yeast Transcriptional Activator SNF2/SWI2,” Cell, vol. 68, pp. 561-572, Feb. 7, 1992.
Robertson et al., 1994; Genomics 23;42-50.
Beck et al., “A homologue of the Drosophila female sterile hemeotic (fsh) gene in the class II region of the human MHC,”DNA Seq1992;2(4):203-10 (abstract).
Haynes et al., “The Drosophila fsh locus, a maternal effect homeotic gene, encodes apparent membrane proteins,”Dev BiolJul. 1989;134(1):246-57 (abstract).
GenBank Accession No. M23221,D. melanogasterfsh membrane protein, 7.6 kb mRNA, complete cds., Apr. 26, 1993.
GenBank Accession No. M23222,D. melanogasterfsh membrane protein, 5.9 kb mRNA, complete cds., Apr. 26, 1993.
GenBank Accession No. M85049,D. melanogasterbrahma protein mRNA, complete cds., Jul. 13, 1994.
GenBank Accession No. M87651,S. cerevisiaebromodomain of SPT7 gene, partial cds., Apr. 27, 1993.
GenBank Accession No. M61703 M55906,S. cerevisiaeSNF2 protein gene, complete cds., Apr. 27, 1993.
GenBank Accession No. X07024,H. sapiensmRNA for CCG1 protein, Jul. 17, 2001.
GenBank Accession No. M80613, human homolog ofDrosophilafemale sterile homeotic mRNA, complete cds., Jun. 22, 1995.
Hillier et al., “Generation and analysis of 280,000 human expressed sequence tags”,Database EMBL 'Online!, Database Assession No. H70181, XP002198410, Oct. 25, 1995.
Hilier et al., “The WashU-Merck EST Project”,Database EMBL 'Online!, Database Assession No. R66814, XP002198411, Jun. 4, 1995.
Hillier et al., “Generation and analysis of 280,000 human expressed sequence tags”,Database EMBL 'Online!, Database Assession No. AA112166, XP002193345, Nov. 9, 1996.
Hillier et al., “Generation and analysis of 280,000 human expressed sequence tags”,Database EMBL 'Online!, Database Assession No. AA102574, XP002193346, Oct. 30, 1996.
Jones et al., “A Novel Family of Bromodomain Genes”,Genomics, 63 pp. 40-45, 2000.
Nicolas et al., “Molecular cloning of polybromo, a nuclear protein containing multiple domains including five bromodomains, a truncated HMG-box, and two repeats of a novel domain”,Gene, 175 pp. 233-240, 1996.
Nielson et al., “Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain”,Biochimica et Biophysica Acta, 1306 pp. 14-16, 1996.
Teresa K. Attwood, “The Babel of Bioinformatics”, 2000, Science, vol. 290(5491);471-473.
Gems et al., “An abundantly expressed mucin-like protein . . .”, 1996, Proc Natl Acad Sci USA, vol. 93(4);1665-1670.
Skolnick et al., “From genes to protein structure and function; novel applications . . .”, 2000, Trends Biotechnol, vol. 18(1);34-39.
Yasui et al., “Identification of Target Genes Within an Amplicon at I4qI2-qI3 in Esophageal Squamous Cell Carcinoma”, Genes Chromosomes Cancer, vol. 32(2), pp. 112-118 (2001).
LeRoy et al., “Purification and Characterization of a Human Factor That Assembles and Remodels Chromatin”, The Journal of Biological Chemistry, vol. 275(20), pp. 14787-14790 (2000).
Bochar et al., “A family of chromatin remodeling factors related to Williams syndrome transcription factor”, Proc. Natl. Acad. Sci. USA, vol. 97(3), pp. 1038-1043 (2000).
Collins et al., “An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin”, Nature Genetics, vol. 32(4), pp. 627-632 (2002).
Fujiki et al., “Ligand-induced transrepression by VDR through association of WSTF with acetylated histones,” EMBO J., 24:3881-3894 (2005).

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