Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-09-20
2011-11-15
Long, Scott (Department: 1633)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C536S063000, C435S006120, C435S320100, C530S350000
Reexamination Certificate
active
08058231
ABSTRACT:
Transcriptional regulatory regions and transcriptional regulatory factors for the human high affinity IgE receptor (FcεRI) γ-chain gene are specified and are targets for the development of transcriptional regulatory agents for the FcεRI γ-chain gene. The following are provided: DNA comprising the full length or a portion of the base sequence shown in SEQ ID NO:1, that regulates transcription of the human high affinity IgE receptor (FcεRI) γ-chain gene; and DNA comprising the full length or a portion of the base sequence shown in SEQ ID NO:2, that regulates transcription of the human high affinity IgE receptor (FcεRI) γ-chain gene. The present invention is promising for the development of novel agents for the prophylaxis/treatment of allergic diseases, autoimmune diseases, thrombosis, glomerulonephritis, and lupus nephritis.
REFERENCES:
patent: 6171803 (2001-01-01), Kinet
Küster, H. et al.,Characterization and Expression of the Gene for the Human Fc Receptor γ Subunit, The Journal of Biological Chemistry, vol. 266, No. 11, Apr. 15, 1990, pp. 6448-6452.
Chisei RA, et al. “A macrophage Fcγ receptor and the mast cell receptor for IgE share an identical subunit”, Nature, vol. 341, pp. 752-754, Oct. 26, 1989.
U. Blank, et al. “Complete structure and expression in transfected cells of high affinity IgE receptor”, Nature vol. 337, pp. 187-189, Jan. 12, 1989.
Jean-Pierre Kinet, “The High-Affinity IgE Receptor (FcεRI): From Physiology to Pathology”, Annu. Rev. Immunol. 1999. 17:931-72.
Hakuoh Konishi, MD, et al. “Platelets Activated by CollagenThrough Immunoreceptor Tyrosine-Based Activation Motif Play Pivotal Role in Initiation and Generation of Neointimal Hyperplasia After Vascular Injury”, Circulation, pp. 912-916, Feb. 26, 2002.
Yusuke Suzuki, et al. “Distinct contribution of Fc receptors and angiotensin II-dependent pathways in anti-GBM glomerulonephritis”, Kidney International, vol. 54 (1998), pp. 1166-1174.
Anna T. Brini, et al. “Involvement of Alu Sequences in the Cell-specific Regulation of Transcription of the γ Chain of Fc and T Cell Receptors”, vol. 268, No. 2, Issue of Jan. 15, pp. 1355-1361, 1993.
Takaaki Tamura, et al., “Transcriptional Control Mechanism and Gene Expression,” Irasuto Igaku & Scienct Series Tensha no Mechanism to Shikkan, Kabushiki Kaisha Yodosha, Apr. 20, 2000, pp. 12 to 19, Table 2.
Masanari Hasegawa, et al. “Regulation of the Human FcεRI γ-Chain Distal Promoter1” The Journal of Immunology., 2003, vol. 170, No. 7, pp. 3732 to 3738.
Robert S. Carter, et al. Cooperative Binding of GA-binding Protein Transcription Factors to Duplicated transcription Initiation Region Repeats of the CytohromecOxidase Subunit IV Gene, The Journal of Biological Chemistry, vol. 269, No. 6, Issue of Feb. 11, pp. 4381-4387, 1994.
Activities of the Atopy Research Center, Juntendo University School of Medicine, Apr. 1998-Mar. 2003.
Activities of the Atopy Research Center, Juntendo University School of Medicine, Apr. 1998-Mar. 2003 (English-language translation of Japanese article submitted in prior IDS).
Ra Chisei
Takahashi Kyoko
Long Scott
Morgan & Lewis & Bockius, LLP
Nihon University
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