Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-11-01
2005-11-01
Carlson, Karen Cochrane (Department: 1653)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S350000, C530S399000
Reexamination Certificate
active
06960444
ABSTRACT:
This invention relates to methods of modulating the development of blood vessels and/or endothelial cell differentiation in a mammal comprising altering the activity of an Ets transcription factor, which activates vascular specific genes. More particularly, the transcription factor comprises ELF-1, and transcription factors that are homologous to ELF-1. The invention further relates to methods of screening for compounds that affect the activity of these transcription factors, and therefore, affect the development of blood vessels and/or endothelial cell differentiation. The invention also relates to methods of using these compounds to treat diseases, or symptoms of diseases, by either increasing or decreasing blood vessel development and/or endothelial cell differentiation.
REFERENCES:
patent: 5721113 (1998-02-01), Libermann et al.
Leiden et al. 1992, J. Virol. 66 (10): 5890-5897.
Nishiyama et al. 2000, BioSci. Biotechnol. Biochem. 64 (12): 2601-2607.
Thompson et al. 1992; Mol. Cell. Biol. 12 (3): 1043-1053.
Libermann Towia
Oettgen Peter
Beth Israel Deaconess Medical Center
Butler Gregory B.
Carlson Karen Cochrane
Conlin David G.
Edwards & Angell LLP
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