Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-02-24
2009-12-08
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S326000, C514S356000, C514S354000
Reexamination Certificate
active
07629471
ABSTRACT:
Ascochlorin or an analog or derivative thereof and a compound having a primary amino group are mixed and reacted with each other in the presence/absence of a basic catalyst to synthesize a novel imino compound. The novel imino compound thus synthesized is a ligand capable of activating nuclear receptor superfamily such as retinoid orphan receptor (RXR), peroxisome proliferator-activated receptor (PPAR) and steroid receptor (PXR), and shows an effect of promoting the transcription of a drug-metabolizing enzyme CYP7A1. The imino compound has a therapeutic effect on diseases such as lifestyle-related diseases, chronic inflammation and cancers.
REFERENCES:
patent: 6413507 (2002-07-01), Bentley et al.
patent: 2-152940 (1990-06-01), None
patent: WO 00/53563 (2000-09-01), None
Ando Kunio
Kitahara Takeshi
Watanabe Hidenori
Cantor & Colburn LLP
Chandrakumar Nizal S
NRL Pharma, Inc.
Seaman D. Margaret
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