Chemistry: molecular biology and microbiology – Vector – per se
Patent
1986-08-15
1988-10-04
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Vector, per se
435 68, 435 70, 435 91, 4351723, 435235, 536 27, 935 27, 935 32, 935 34, 935 56, C12P 2100, C12P 1900, C12N 1500, C07H 1512
Patent
active
047756306
ABSTRACT:
A novel alteration of a viral DNA sequence, derived from a human adenovirus type 3 mutant (Ad3) designaed Ad3h15, provides a transcriptional control element which can be used to regulate expression of a selected gene in animal and human cells. The Ad3h15 control element blocks transcription of a controlled gene in the presence of the products of the Ad3 E1A gene, and amplifies transcription in the presence of type 5 (Ad5) adenovirus E1A gene products.
REFERENCES:
Borrelli et al., Nature, vol. 312, 13 Dec. 1984, pp. 608-612, "Adenovirus-2 E1A Products Repress Enhancer Induced Stimulation of Transcription".
Larsen et al., (Including Christine Robinson), Virology, vol. 155, pp. 148-159, Nov. 1986, 3: Ad3hr15 "An E1A Mutant Type has Reiterated DNA Sequences 5' to its E1A Gene."
Hearing et al., Cell, vol. 33, pp. 695-703, Jul. 1983, "The Adenovirus Type 5 E1A Transcriptional Control Element Contains a Duplicated Enhancer Element".
Robinson et al., Virology, vol. 137, pp. 276-284, 1984, "Polar Encapsidation of Adenovirus DNA: Evolutionary Variants Reveal Dispensible Sequences Near the Left Ends of Ad3 Genomes."
Leite et al., Gene, vol. 41, Apr. 1986, pp. 207-215, "Expression of the Chloramphenicol Acetyl Transferase Gene in Human Cells . . . Other Subgroups on Gene Expression".
Kostruko et al., J. Virology, vol. 43(3), pp. 1132-1137, Sep. 1986, "Polardencapsidation of Adenovirus DNA: Cloning and DNA Sequence of the Left end of Ad type 3".
Hearing et al., Cell, vol. 45, pp. 229-236, Apr. 25, 1986, "The Adenovirus Type 5 E1A Enhancer Contains Two Functionally Distinct Domains: One is Specific . . . Units in Cis".
Kaufman, Proc. Natl. Acad. Sci., vol. 82, pp. 689-693, Feb. 1985, "Identification of the Components Necessary for Adenovirus Translational Control . . . Expression Vectors".
Larsen et al., Virology, vol. 147, pp. 187-200, Nov. 1985, "Spontaneous Reiterations of DNA Sequences Near the Ends of Adenovirus Type 3 Genomes".
Tibbetts et al., J. Virology, vol. 57(3), Mar. 1986, "Autoregulation of Adenovirus E1A Gene Expression".
Jones Stephen N.
Larsen Pamela L.
McGrane Mary M.
Tibbetts Clark
Teskin Robin L.
Vanderbilt University
Wiseman Thomas G.
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