Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2006-08-08
2006-08-08
McKelvey, Terry (Department: 1636)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S324000, C530S350000
Reexamination Certificate
active
07087711
ABSTRACT:
The present invention describes novel transcriptional activators and activation systems. The activators of the present invention comprise a DNA binding moiety linked to a short peptide of novel sequence. Preferably, the peptide is substantially hydrophobic. Preferred peptides include at least one aromatic amino acid. The present invention also provides improved transcriptional activation systems, useful for the identification and characterization of protein—protein interactions. The invention also describes the production and use of certain TBP mutants that enhance transcriptional activation by some activators.
REFERENCES:
patent: 6326166 (2001-12-01), Pomerantz et al.
Lu Xiangyang
Ptashne Mark
Wu Yibing
Choate Hall & Stewart LLP
McKelvey Terry
President and Fellows of Harvard College
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